Pulmonary fibrosis (PF) remains a devastating disease. Copper (Cu), an essential trace element, has been implicated in fibrotic processes in various organs, including the lungs. This study investigated the potential protective effects of trientine (TRI), a copper chelator, against bleomycin (BLM)-induced PF in rats and explored the underlying mechanisms. PF was induced by intratracheal administration of BLM (5 mg/kg). Rats wer...

Water deficit stress significantly threatens faba bean productivity, highlighting the need to understand cultivar-specific drought tolerance mechanisms to improve breeding efforts. This study aimed to assess the morphological, physiological, and biochemical responses of three faba bean cultivars exposed to different drought levels during the vegetative and flowering stages. Three cultivars (Qidou2, Chenghu10, and Qinghai13) we...

The study was carried out to examine the sustainable management of irrigation water for olive cultivation in sandy soils with varying levels of water salinity at a farm situated in the Regwa region of EL-Beheira Governorate, Egypt, which is noted for its arid climate, aiming to improve the effective utilization of sustainable ecosystems while optimizing economic returns for agricultural producers. Field experiments were implem...

The current global context stimulating agroecology and green agriculture need to explore for the novel sustainable and eco-conscious methods for safeguarding plants. The aim of this study is to exploit the rich contents of date palm seeds (DPS) as an appropriate organic elicitor to boost growth and plant secondary metabolism in Eruca vesicaria . The seeds of DPS were utilized in the extraction process using distilled water to...

Identifying novel natural sources from the marine environment with unique immunomodulatory and antioxidant efficacies is of interest in intensive fish farming. In this sense, marine sponge extract derived from Smenospongia (SS-extract) was tested for its potential anti-inflammatory, antioxidant and antimicrobial activities during the concurrent infection with Trichodina sp. and Flavobacterium columnare in Nile tilapia. A total...

Assessment of acute toxicity of magnetic nanogel (MNG) is crucial to conclude the safe applicable dose and to warrant its application in aquaculture. Therefore, the current study is a novel step to assess behavior, neuro-stress response, hepato-renal, oxidative, and histopathological variations produced by MNG’ acute toxicity in Clarias gariepinus . Two experiments were conducted: the first was a determination of the 96-h leth...

Colorectal cancer (CRC) is a prevalent cancer with high morbidity and mortality rates worldwide. Late diagnosis is a significant contributor to low survival rates in a minority of cases. The study aimed to perform a robust pipeline using integrated bioinformatics tools that will enable us to identify potential diagnostic and prognostic biomarkers for early detection of CRC by exploring differentially expressed genes (DEGs). In...

Background Adiposity and non-alcoholic fatty liver disease (NAFLD) are common characteristics of metabolic syndrome (MS). Understanding the underlying pathogenesis is crucial for the development of new remedies. Resveratrol controls obesity and glycemic disorders in patients with MS. Objectives This study aimed to evaluate the effect of resveratrol and dulaglutide on adipose tissues and liver in rats with MS, declaring their p...