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Springer Nature1
Journal
Psychopharmacology1
Publication Year
20211
Avi Reichenberg results 1 · Newest (Page 1/1, per page 25)
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Author: Avi Reichenberg ×Clear All Filters
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An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patientsNARA Subscribed
Psychopharmacology · 2021 · Vol. 238 · Issue 5 · Springer
James Gilleen; Yakub Farah; Cate Davison; Sarah Kerins; Lorena Valdearenas; Tolga Uz; Gez Lahu; Max Tsai; Frank Ogrinc; Avi Reichenberg; Steve C. Williams; Mitul A. Mehta; Sukhi S. Shergill
Rationale Schizophrenia is associated with impairments in cognitive functioning yet there are no approved drugs to treat these deficits. Objectives Based on animal models, we investigated the potential for roflumilast, a selective inhibitor of phosphodiesterase type 4 (PDE4), to improve cognition, which may act by increasing intracellular cyclic adenosine monophosphate in brain regions underlying cognitive deficits in schizoph...
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