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Naunyn-Schmiedeberg's Archives of Pharmacology · 2026 · Vol. 399 · Issue 2 · Springer
Upper gastrointestinal endoscopy (GIE) is essential for diagnosing and treating gastrointestinal disorders in children aged 6–12 years, yet it often requires sedation due to the significant discomfort and pain involved. We conducted a PRISMA 2020–compliant systematic review of randomized controlled trials (RCTs) from PubMed, Web of Science, Scopus, and Ovid (inception to March 30, 2024). Inclusion criteria are as follows: RCTs...
Environmental Geochemistry and Health · 2024 · Vol. 46 · Issue 10 · Springer
Due to water shortages and the potential impact of Ethiopia’s new dam on the Nile River, Egypt is seeking new water resources. This study assesses the drinking water quality and associated risks from potentially toxic elements (PTEs) in the Quaternary aquifer (QA) in Beni-Suef, Egypt. Using a comprehensive approach, including PHREEQC geochemical modeling, ionic ratios, multivariate statistical analyses, and the integrated weig...
Journal of Pharmaceutical Investigation · 2024 · Vol. 54 · Issue 4 · Springer
Purpose Up-to-date literature offers limited data about utilizing atorvastatin calcium (ATV) as a promising chondroprotective agent in osteoarthritis (OA). So, this study aims to develop a depot intra-articular (IA) delivery system for ATV to enhance its deposition in the articular joint. Methods A 3 3 D-optimal design was implemented to prepare ATV-loaded lecithin-coated zein nanoparticles. The optimized formulation (Opt-LCZN...
Aquaculture International · 2024 · Vol. 32 · Issue 1 · Springer
The aim of this study is to identify the hidden etiologies of the black chromo-shifting transient phenomenon affecting Nile tilapia, Oreochromis niloticus , farmed in RAS-controlled ponds together with the assessment of the immunological reaction against the chronic irritating effects of the invasive agent. A total of 100 Nile Tilapia were collected from a private farm at Kafrelsheikh Province, located on the northern side of...
Inflammopharmacology · 2023 · Vol. 31 · Issue 5 · Springer
Dysregulation of protein homeostasis, proteostasis, is a distinctive hallmark of many neurodegenerative disorders and aging. Deleteriously, the accumulation of aberrant proteins in Alzheimer’s disease (AD) is accompanied with a marked collapse in proteostasis network. The current study explored the potential therapeutic effect of vardenafil (VAR), a phosphodiesterase-5 inhibitor, in AlCl 3 / d -galactose ( d -gal)-induced AD i...