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Springer Nature1
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Mammalian Genome1
Publication Year
20211
Axel Rasche results 1 · Newest (Page 1/1, per page 25)
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Alternative exon splicing and differential expression in pancreatic islets reveals candidate genes and pathways implicated in early diabetes developmentNARA Subscribed
Mammalian Genome · 2021 · Vol. 32 · Issue 3 · Springer
Sayeed ur Rehman; Tanja Schallschmidt; Axel Rasche; Birgit Knebel; Torben Stermann; Delsi Altenhofen; Ralf Herwig; Annette Schürmann; Alexandra Chadt; Hadi Al-Hasani
Type 2 diabetes (T2D) has a strong genetic component. Most of the gene variants driving the pathogenesis of T2D seem to target pancreatic β-cell function. To identify novel gene variants acting at early stage of the disease, we analyzed whole transcriptome data to identify differential expression (DE) and alternative exon splicing (AS) transcripts in pancreatic islets collected from two metabolically diverse mouse strains at 6...
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