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The present study provides an integrated approach to the shear behavior and strength prediction of FRC beams reinforced with fiber-reinforced polymer (FRP). For this purpose, a database consisting of 68 beam test results in the literature for the assessment of 10 existing shear strength models and design code provisions for FRC beams reinforced by FRP reinforcement, together with the newly proposed analytical model that has be...
Traditional drilling muds frequently have trouble efficiently transporting cuttings to the surface, which impedes drilling efficiency and progress. The possibility of a nano addition to enhance the cutting transport capability of water-based muds (WBM) is examined in this work. This study employed graphene nanoplatelets (GNPs)-based drilling muds made from rice husk waste and modified with Triton-X100 to determine how sandston...
Inflammatory microglia signals drive A1-like polarization of astrocytes even in the presence of HIV-1 TatNARA Subscribed
In the context of neurodegeneration, activated microglia facilitate inflammation via secretion of TNF-α, IL-1α, and C1q. Astrocytes exposed to this signaling array polarize to a reactive inflammatory phenotype, termed A1 or A1-like. Astrocytes are essential for neuronal survival, synaptic support, and blood–brain barrier (BBB) function, but A1-like astrocytes upregulate inflammatory gene expression, downregulate neurotrophic f...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Summary Bacillus pseudofirmus OF4 is an extreme but facultative alkaliphile that grows non‐fermentatively in a pH range from 7.5 to above 11.4 and can withstand large sudden increases in external pH. It is a model organism for studies of bioenergetics at high pH, at which energy demands are higher than at neutral pH because both cytoplasmic pH homeostasis and ATP synthesis require more energy. The alkaliphile also tolerates a...
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