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Insight into the mechanism of action of ORG27569 at the cannabinoid type one receptor utilising a unified mathematical modelNARA Subscribed
Allosteric modulation of CB 1 is therapeutically advantageous compared to orthosteric activation as it potentially offers reduced on-target adverse effects. ORG27569 is an allosteric modulator that increases orthosteric agonist binding to CB 1 but decreases functional signalling. ORG27569 is characterised by a delay in disinhibition of agonist-induced cAMP inhibition (lag); however, the mechanism behind this kinetic lag is yet...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
In marine management, fish stocks are often managed on a stock‐by‐stock basis using single‐species models. Many of these models are based upon statistical techniques and are good at assessing the current state and making short‐term predictions; however, as they do not model interactions between stocks, they lack predictive power on longer timescales. Additionally, there are size‐based multi‐species models that represent key bi...
Farewell Stan Stanley Falkow: 1934–2018NARA Subscribed
Winter diet composition of brown trout Salmo trutta was quantified from November to March in 35 temperate groundwater‐dominated streams in south‐eastern Minnesota, U.S.A., in relation to stream physical characteristics including drainage area, channel slope and influence of groundwater on stream thermal regime. Aquatic invertebrates made up the majority of S. trutta diet in all streams and sampling periods and individual S. tr...
Dissolved nitrogen (N) as urea ([NH 2 ] 2 CO), nitrate (NO ‐ 3 ), and ammonium (NH + 4 ) was added to naturally phosphorus (P)‐rich lake water (up to 175 µg P L ‐1 ) to test the hypotheses that pollution of hypereutrophic lakes with N increases total algal abundance, alters community composition, and favors toxic cyanobacteria that do not fix atmospheric N 2 . Monthly experiments were conducted in triplicate in polymictic Wasc...
Magnitudes and controls of organic and inorganic carbon flux through a chain of hard‐water lakes on the northern Great PlainsNARA Subscribed
Whole‐lake carbon (C) mass‐balance budgets were constructed for a chain of six hard‐water lakes to quantify the relative importance of organic carbon (OC) and inorganic carbon (IC) exchanges between atmosphere, water column, sediments, and rivers. Mean summer C fluxes were calculated for each lake during the ice‐free periods (May to September) of 1995‐2007 by measuring deposition of IC and OC in lake sediments, export of C to...
Experimental evidence that pollution with urea can degrade water quality in phosphorus‐rich lakes of the Northern Great PlainsNARA Subscribed
Urea is the most abundant nitrogen (N) fertilizer used on agricultural soils, yet its effects on adjacent aquatic ecosystems are largely unknown. Here 21‐d, 3000‐liter mesocosm experiments were conducted monthly in a hypereutrophic lake during July–September 2007 to quantify how addition of urea might affect phytoplankton abundance, gross community composition, and algal toxicity in a phosphorus (P)‐rich lake. Repeated measure...