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Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Many fisheries in the world are data-moderate, with data types (e.g., total removals, abundance indices, and biological composition data) of varied quality (e.g., limited time series or representative samples) or available data. Integrated stock assessments are useful tools for data-moderate fisheries as they can include all available information, can be updated due to the availability of more information over time, and can di...
Located in the critical 1p36 microdeletion region, the chromodomain helicase DNA-binding protein 5 ( CHD5 ) gene encodes a subunit of the nucleosome remodeling and deacetylation (NuRD) complex required for neuronal development. Pathogenic variants in six of nine chromodomain (CHD) genes cause autosomal dominant neurodevelopmental disorders, while CHD5 -related disorders are still unknown. Thanks to GeneMatcher and internationa...
The biology, ecology and history of toheroa ( Paphies ventricosa ): a review of scientific, local and customary knowledgeNARA Subscribed
Toheroa ( Paphies ventricosa ) were formerly abundant on west and south‐facing New Zealand surf beaches. Harvesting of this surf clam was intense during the early to mid‐1900s, and populations declined to levels where harvesting was no longer viable. Despite having now been protected for 35–45 years, toheroa have failed to recover. This paper reviews the history of human interactions with toheroa and our understanding of their...
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