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Urban wastewater systems represent important interfaces between human activity and the environmental occurrence of antimicrobial resistance (AMR) markers. We assessed the temporal dynamics of intI1 , ermB , and the 16 S rRNA gene by quantitative PCR across three wastewater systems (EPC, CJC, and JW) in Fortaleza, Brazil, from November 2021 to November 2023. Bacterial communities were additionally characterized by 16 S rRNA gen...
Cognition as a global biological processNARA Subscribed
Subgroup-Specific Associations of GRIA Genes Encoding AMPA Glutamate Receptor Subunits with Patient Survival in MedulloblastomaNARA Subscribed
Brain cancers hijack biological systems involved in neural development and synaptic plasticity. Medulloblastoma (MB), the most common malignant brain tumor in children, is thought to arise from disruptions in neurodevelopmental programs. Glutamatergic transmission mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs) has been implicated in synaptic communication between adult brain tumors a...
Introduction: Lung cancer remains one of the leading causes of death worldwide, accounting for approximately 1.8 million deaths annually. In this context, low health literacy is frequent and represents a barrier to effective education on screening and early detection. The aim of this study was to translate, culturally adapt, and validate the Lung CAM questionnaire for use in Brazil, enabling the assessment of population litera...
Cell fate determination and terminal differentiation are shaped by intrinsic molecular programs that coordinate lineage-specific gene expression. In mesenchymal stem cells (MSCs), variability in osteogenic efficiency among distinct tissue sources remains poorly understood and cannot be fully explained by differentiation conditions alone. Increasing evidence indicates that post-transcriptional regulatory mechanisms, particularl...
Myeloperoxidase (MPO) has been associated with a broad range of chronic inflammatory diseases since activated MPO catalyzes the production of HOCl, triggering both oxidative stress and inflammation. Since benzohydrazides are known as MPO inhibitors, a series of six N '-phenylbenzohydrazides and one quinazolin-4(3 H )-one analogue was evaluated through in vitro assays to measure inhibition of MPO, superoxide dismutase (SOD), an...
Speciation is rarely observable directly. A way forward is to compare pairs of ecotypes that evolved in parallel in similar contexts but have reached different degrees of reproductive isolation. Such comparisons are possible in the marine snail Littorina saxatilis by contrasting barriers to gene flow between parallel ecotypes in Spain and Sweden. In both countries, divergent ecotypes have evolved to withstand either crab preda...