Acute respiratory exacerbations in bronchiectasis are important as they impair quality of life and are associated with accelerated lung function decline. Yet, no validated methods exist to identify children at increased risk of exacerbations. We therefore determined if peripheral blood gene expression (GE) signatures can identify those at risk of an impending exacerbation. Thirty-one children with bronchiectasis had RNA extrac...

Increasing water scarcity and nutrient demand requires efficient irrigation and nutrient management for sustaining the productivity of the basmati rice–wheat cropping system. This study assessed the impacts of two irrigation methods (surface [DI] and subsurface drip irrigation [SDI]), four irrigation schedules (I 15% , I 25% , I 35% and I 45% , i.e., 15%, 25%, 35% and 45% depletion of available water) and two nitrogen doses (1...

Whether endovascular thrombectomy (EVT) improves functional outcome in patients with large-vessel occlusion (LVO) stroke that do not comply with inclusion criteria of randomized controlled trials (RCTs) but that are considered for EVT in clinical practice is uncertain. We aimed to systematically identify patients with LVO stroke underrepresented in RCTs who might benefit from EVT. Following the premises that (i) patients witho...