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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Given the growing global interest in Healthy Longevity Medicine (HLM), the field lacks understanding about public knowledge and interest, which are crucial for any public health intervention relying on HLM. This study presents findings from the Healthy Longevity (HELO) survey conducted in Singapore, assessing public knowledge regarding lifespan (number of years a person is alive), healthspan (number of years a person spends in...
Under the current global biodiversity crisis, there is a need for automated and noninvasive monitoring techniques that can gather large amounts of data cost‐effectively at various ecological scales, from local to large spatial scales. These data can then be analyzed to inform stakeholders and decision‐makers. One such technique is passive acoustic monitoring, which is commonly coupled with automatic identification of animal sp...
Towards Precision Geromedicine in SingaporeNARA Subscribed
Since the discovery that ageing is a modifiable process in animal models, significant advancements in geroscience have led to the emergence of the field of Precision Geromedicine, which aims to optimise health and healthspan by targeting ageing-related processes. Ageing-related diseases (ARDs), accounting for 80% of Singapore’s disease burden in 2019, are on the rise as the nation approaches the “super-aged” status by 2030. In...
Plio‐Pleistocene Climatic Fluctuations and Divergence With Gene Flow Drive Continent‐Wide Diversification in an African BirdNARA Subscribed
Diversification mechanisms in Sub‐Saharan Africa have long attracted research interest, with varying support for either allopatric or parapatric models of speciation. However, studies have seldom been performed across the entire continent, a scale which could elucidate the relative importance of allopatric and parapatric models of divergence. To shed light on continental‐scale patterns of African biogeography and diversificati...
Decorin Knockdown Improves Aged Tendon Healing by Enhancing Recovery of Viscoelastic Properties, While Biglycan May NotNARA Subscribed
The objective of the study was to determine the specific roles of decorin and biglycan in the early and late phases of tendon healing in aged mice. Aged (300 day-old) female wildtype (WT), Dcn flox/flox (I- Dcn -/- ), Bgn flox/flox (I- Bgn -/- ), and compound Dcn flox/flox /Bgn flox/flox (I- Dcn -/- /Bgn -/- ) mice with a tamoxifen (TM) inducible Cre underwent a bilateral patellar tendon injury (PT). Cre excision of the condit...
The global population is ageing and the gap between lifespan (total years lived) and healthspan (years lived free of diseases) is increasing. Healthy Longevity Medicine (HLM) is an approach to optimise health and healthspan, and it has substantial public health implications. Despite those implications, the understanding of public perspectives on this field is lacking. The HEalthy LOngevity (HELO) framework was developed throug...
Motivation Pollinators play a crucial role in maintaining Earth's terrestrial biodiversity. However, rapid human‐induced environmental changes are compromising the long‐term persistence of plant‐pollinator interactions. Unfortunately, we lack robust, generalisable data capturing how plant‐pollinator communities are structured across space and time. Here, we present the EuPPollNet (European Plant‐Pollinator Networks) database,...
SNAPSHOT USA 2019–2023: The First Five Years of Data From a Coordinated Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multicontributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of specie...
Healthy longevity medicine integrates geroscience and other disciplines into clinical settings, aiming to optimize health throughout one’s lifespan. Multiple factors have led to increased consumer engagement, with private clinics currently meeting the demand for guidance to improve healthy longevity. The establishment of healthy longevity clinics in publicly funded hospitals is a significant development, making longevity-focus...