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Understanding how genetic variants influence disease risk through molecular mechanisms remains a central challenge in complex disease genetics. Nonsyndromic orofacial clefts (OFCs) exemplify this challenge, with most risk loci residing in non-coding regions. We hypothesized that common genetic variants influence OFC risk by modulating DNA methylation at regulatory elements through methylation quantitative trait loci (meQTLs)....
The Asia region harbors exceptional chondrichthyan (shark, ray, and chimaera) diversity but faces intense fishing pressure. The Important Shark and Ray Areas (ISRA) process provides a collaborative, evidence-based framework to identify critical habitats and inform spatial management. We assessed ISRAs across the Bay of Bengal, Southeast Asia, and the Northwest Pacific to characterize their extent, ecological significance, and...
Prevalence and determinants of ageism experiences in the Singapore population: insights from the HEalthy LOngevity (HELO) surveyNARA Subscribed
Ageism refers to stereotypes, prejudice, and discrimination based on age. Ageism negatively impacts physical and mental health across the lifespan, yet knowledge about the experience of ageism in Singapore is limited. This study evaluated the prevalence of experienced ageism in Singapore and identified its key determinants within a nationally representative cohort. In the cross-sectional HEalthy LOngevity (HELO) survey ( N = 3...
Identifying populations at highest risk from climate change is a critical component of conservation efforts. However, vulnerability assessments are usually applied at the species level, even though intraspecific variation in exposure, sensitivity and adaptive capacity play a crucial role in determining vulnerability. Genomic data can inform intraspecific vulnerability by identifying signatures of local adaptation that reflect...
Previous research has shown that female and Hispanic students who are underrepresented in science, technology, engineering and mathematics (STEM) face more educational barriers than their non-Hispanic, male peers. However, little research has been conducted on the effects of intersectional identities in the STEM space. In an effort to bridge the gap in underrepresented students' experience, the PSEG Institute for Sustainabilit...
Molecular Mechanisms Underlying Response to Influenza in Grey Seals ( Halichoerus grypus ), a Potential Wild ReservoirNARA Subscribed
RNA viruses are infamous for their ability to cross species barriers, posing threats to global health and security. Influenza A virus (IAV) is naturally found in avian hosts but periodically spills over into marine wildlife. IAV outbreaks occur in the Northwest Atlantic, but grey seals ( Halichoerus grypus ) appear to be less susceptible to IAV compared to other species. The subclinical nature of IAV infection in addition to l...
New values for accumulation of unerupted magma inside Mt Etna volcano, determined from 42 years of ground deformation dataNARA Subscribed
Volcanoes grow and change shape by eruption, magma intrusion and by spreading outwards under their own weight. To understand the workings of a volcano, the balance of these processes must be quantified, requiring decades of observation. Here, we measure displacement of 72 survey points on and around Mt Etna to millimetre accuracy for periods of up to 42 years. We find that Etna is increasing in volume by 2.68 million cubic met...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Trans‐Specific Polymorphisms Between Cryptic Daphnia Species Affect Fitness and BehaviorNARA Subscribed
Shared polymorphisms, loci with identical alleles across species, are of unique interest in evolutionary biology as they may represent cases of selection maintaining ancient genetic variation post‐speciation, or contemporary selection promoting convergent evolution. In this study, we investigate the abundance of shared polymorphism between two members of the Daphnia pulex species complex. We test whether the presence of shared...
Minimum information for reporting on the TEER (trans-epithelial/endothelial electrical resistance) assay (MIRTA)NARA Subscribed
Standard information reporting helps to ensure that assay conditions and data are consistently reported and to facilitate inter-laboratory comparisons. Here, we present recommendations on minimum information for reporting on the TEER (trans-epithelial/endothelial electrical resistance) assay (MIRTA). The TEER assay is extensively used to evaluate the health of an epithelial/endothelial cell culture model and as an indicator of...
Animals within social groups respond to costs and benefits of sociality by adjusting the proportion of time they spend in close proximity to other individuals in the group (cohesion). Variation in cohesion between individuals, in turn, shapes important group‐level processes such as subgroup formation and fission–fusion dynamics. Although critical to animal sociality, a comprehensive understanding of the factors influencing coh...