Rationale Synthetic opioids like fentanyl are contributing to unprecedented overdose rates, yet the neural circuitry underlying fentanyl-associated behaviors remains poorly understood. The ventral tegmental area (VTA) projects to both the nucleus accumbens (NAc) and prefrontal cortex (PFC), forming distinct pathways that are implicated in drug-cue associations, though their specific roles in fentanyl-context encoding are not w...

Fish frame waste (FW) from threadfin breams ( Nemipterus japonicus ) was valorized into functional fish protein hydrolysates (FPH) using proteases from plant (ficin), microbial (neutrase), fungal and endogenous visceral sources for potential food and nutraceutical applications. A comparative enzymatic hydrolysis approach was adopted for evaluating influence of enzyme source and degree of hydrolysis (DH) on bioactivity and func...

Key message Field-based phenotyping of root system architectural (RSA) traits in a diversity panel (PI-GAP) of pigeonpea was conducted across three diverse pigeonpea growing environments along with identification of genomic regions associated with these traits through GWAS analysis. Abstract Root system architecture (RSA) plays a crucial role in plant stress tolerance mechanisms serving as the main route for water and nutrient...

SH2 (Src Homology 2) domains play a crucial role in phosphotyrosine-mediated signaling and have emerged as promising drug targets, particularly in cancer therapy. STAT3 (Signal Transducer and Activator of Transcription 3), which contains an SH2 domain, plays a pivotal role in cancer progression and immune evasion because it facilitates the dimerization of STAT3, which is essential for their activation and subsequent nuclear tr...