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Besor 37 is an open-air site in the northwestern Negev Desert (Israel). Excavations at the site in 2020 uncovered a rich, in situ Middle Paleolithic assemblage composed of flint and limestone artifacts, animal bones and charcoal. The good preservation of the site is due to its rapid burial by overbank deposition of fluvially reworked loess. Dating using both Optically Stimulated Luminescence and 14 C suggests an average age of...
Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Mechanisms driving variation in American marten winter rest site use across the Western Great Lakes RegionNARA Subscribed
At high latitudes, the thermal protection of snowpack is important for many small-bodied mammal species during the winter. As depth and persistence of snow changes due to climate change, species that rely on snowpack’s insulation must increasingly depend on alternative thermal refuges. For the American marten ( Martes americana ), winter rest sites are predominantly in ground microsites. In some regions, however, martens prima...
Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous miceNARA Subscribed
Mice bred in 2021 were tested by the Interventions Testing Program (ITP) for possible lifespan benefits of 2BAct (2BA), dichloroacetate (DCA), Epicatechin (EPI), Forskolin (FSK), Halofuginone (HAL) and Mitoglitazone (MIT). All agents were administered in the diet ad libitum beginning at 7 months of age. In male mice, EPI increased median lifespan by ~ 5%, and HAL and MIT each increased median lifespan by ~ 9%. EPI and HAL, but...
End-of-life pathology in UM-HET3 mice treated with 16 α‑hydroxyestradiol or late‑start canagliflozinNARA Subscribed
Canagliflozin (Cana) started at 16 months of age and 16-hydroxy-estradiol (OH_Est) started at 12 months each led to significant increases in lifespan in male UM-HET3 mice but significant decreases in female lifespan. To seek insights into the basis for these sex-specific effects, we performed end-of-life histopathological analyses of control and treated mice for all three interventions testing program sites. There were no sign...
Background Soluble Fms-like Tyrosine kinase-1 (sFLT1) is a native inhibitor of VEGF, best known for its antiangiogenic effects in preeclampsia. sFLT1 also reduces chronic inflammation and promotes tissue repair. In experimental diabetic nephropathy, we previously found that sFLT1 ameliorates kidney fibrosis and reduces the infiltration of macrophages. How sFLT1 regulates inflammation is still incompletely understood. Based on...
Resilient plants, sustainable futureNARA Subscribed
Understanding the role of apex predators on ecosystems is essential for designing effective conservation strategies. Supporting recovery of apex predators can have many benefits; one that has been rarely examined is control of invasive prey. We investigated whether a recovering apex predator, the southern sea otter ( Enhydra lutris nereis ), can exert local control over a global marine invader, the green crab ( Carcinus maenas...
Mixed effect estimation in deep compartment models: Variational methods outperform first-order approximationsNARA Subscribed
This work focusses on extending the deep compartment model (DCM) framework to the estimation of mixed-effects. By introducing random effects, model predictions can be personalized based on drug measurements, enabling the testing of different treatment schedules on an individual basis. The performance of classical first-order (FO and FOCE) and machine learning based variational inference (VI) algorithms were compared in a simul...
What drives the evolution of body size in ectotherms? A global analysis across the amphibian tree of lifeNARA Subscribed
Aim The emergence of large‐scale patterns of animal body size is the central expectation of a wide range of (macro)ecological and evolutionary hypotheses. The drivers shaping these patterns include climate (e.g. Bergmann's rule), resource availability (e.g. ‘resource rule’), biogeographic settings and niche partitioning (e.g. adaptive radiation). However, these hypotheses often make opposing predictions about the trajectories...
Successful restoration of archived ovine formalin fixed paraffin-embedded tissue DNA and single nucleotide polymorphism analysisNARA Subscribed
Archived formalin fixed paraffin-embedded (FFPE) tissues are powerful tools in medicine, capable of harboring diagnostic and genetic answers to challenging clinical questions. Successful utilization of DNA derived from FFPE samples is dependent upon repairing DNA damage generated from the fixation process. Methods to repair FFPE DNA have been successful in human medicine for a variety of research and clinical applications, yet...
Several classes of pesticides have been shown to impair water quality in California, including organophosphates, pyrethroids and neonicotinoids. Vegetative treatment systems (VTS) can reduce pesticide loads and associated toxicity in agricultural runoff, but many water-soluble pesticides such as neonicotinoids are not effectively treated by VTS, and VTS installation is not always an option for growers required to remove non-cr...