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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Seaweed aquaculture is rapidly growing globally and offers environmental benefits such as reducing eutrophication and increasing biodiversity. Sweden has a long coast with favorable conditions for seaweed cultivation, but the current industry remains small. Over the past decade, several innovative research projects have explored and developed techniques tailored toward sustainable seaweed aquaculture. This study synthesizes re...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Salinity and host drive Ulva ‐associated bacterial communities across the Atlantic–Baltic Sea gradientNARA Subscribed
The green seaweed Ulva is a model system to study seaweed–bacteria interactions, but the impact of environmental drivers on the dynamics of these interactions is little understood. In this study, we investigated the stability and variability of the seaweed‐associated bacteria across the Atlantic–Baltic Sea salinity gradient. We characterized the bacterial communities of 15 Ulva sensu lato species along 2,000 km of coastline in...
The ubiquitous and species rich genus Ulva comprises entities of green macroalgae with variable morphologies. Ulva species are important from ecological and economic perspectives, but their identification is often problematic. Current knowledge on Ulva diversity has focused mainly on foliose individuals of temperate regions, but genetic and morphological data on tubular species are often insufficient and the species richness i...
Adherence of kelp (Saccharina latissima) gametophytes on ropes with different binder treatments and flow regimesNARA Subscribed
The cultivation of kelp typically involves two stages, where an indoor hatchery phase preceedes the grow-out phase at-sea. The in situ adhesion of microscopic propagules onto specifically designed substrates using binders has been proposed as an alternative to conventional hatchery methods where juvenile seaweeds are cultured on seeded twine, aimed at saving resources while increasing productivity as it obviates the hatchery p...
The Holocene reefs off southeast Florida provide unique insights into the biogeographical and ecological response of western Atlantic coral reefs to past climate change that can be used to evaluate future climate impacts. However, previous studies have focused on millennial-scale change during the stable mid-Holocene, making it difficult to make inferences about the impact of shorter-term variability that is relevant to modern...
There is an increasing interest in the cultivation of seaweeds for food and feed, and the seaweed aquaculture industry is rapidly developing. The nutritional status of the seaweeds is important to ensure a good quality crop. Cost-efficient and straightforward methods for farmers to analyze their crop are essential for the successful development of the industry. In this study, we developed non-destructive, labor- and cost-effic...
Ancient DNA (aDNA) has been applied to evolutionary questions across a wide variety of taxa. Here, for the first time, we utilized aDNA from millennia‐old fossil coral fragments to gain new insights into a rapidly declining western Atlantic reef ecosystem. We sampled four Acropora palmata fragments (dated 4215 BCE to 1099 CE) obtained from two Florida Keys reef cores. From these samples, we established that it is possible both...
Seaweed aquaculture can provide the growing human population with a sustainable source of proteins. Sea-based cultivation is an effective method for farming seaweeds on a large scale and can yield high biomass output. However, the quality and biochemical composition of the biomass is seasonally dependent, which limits the harvests to certain periods of the year. Here we show the possibility to extend the sea-based cultivation...
Ulva spp. (sea lettuce) has recently gained attention as a sustainable protein source due to its high productivity and many nutritional properties interesting for the food industry. In this study, we explored a possible industrial symbiosis between herring production processing industries and Ulva fenestrata cultivation. We show that U. fenestrata cultivated in herring production process waters had four to six times higher bio...
Sea lettuce ( Ulva ) aquaculture has increased the last decade due to high productivity, wide environmental tolerance, and interesting functional and nutritional properties of the crop. Research focus has mainly been on adult biomass production, but knowledge of performance and biochemical content of early developmental stages – which are the basis to any large-scale production - is still limited. The life-history of Ulva alte...
Seaweed biomass is a renewable resource with multiple applications. Sea-based cultivation of seaweeds can provide high biomass yields, low construction, operation, and maintenance costs and could offer an environmentally and economically sustainable alternative to land-based cultivations. The biochemical profile of sea-grown biomass depends on seasonal variation in environmental factors, and the optimization of harvest time is...
Genetic structure and diversity of the mustard hill coral Porites astreoides along the Florida Keys reef tractNARA Subscribed
Increases in local and global stressors have led to major declines in coral populations throughout the western Atlantic. While abundances of other species have declined, however, the relative abundance of the mustard hill coral, Porites astreoides , has increased. Porites astreoides is relatively resilient to some stressors, and because of its mixed reproductive strategies, its populations often recover quickly following distu...