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Climate change is reshaping coastal ecosystems through gradual warming and increasingly frequent extreme heat events, potentially affecting native and introduced species differently. We experimentally compared the native marine snail Littorina obtusata , a habitat and dietary specialist, to the introduced generalist Littorina littorea under sustained warming and short-term extreme heat. We measured survival and performance met...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
High-density fluids in diamonds from No. 50 kimberlite pipe, Wafangdian, China: the connection to kimberlitesNARA Subscribed
We report the major and trace element composition of high-density fluids (HDFs) trapped in microinclusions in 14 diamonds from Wafangdian, Liaoning, China. This is the first detailed report of the major and trace elements of HDFs from the North China Craton. The trapped fluids are similar to those known from other localities, except for one with a unique Cl-K-Ba-Sr-rich composition that is also extremely enriched in Th and the...
Ecological and Anthropogenic Drivers of Red Fox ( Vulpes vulpes ) Abundance and Site Use Across the Contiguous USANARA Subscribed
Aim Understanding species abundance and distribution is fundamental for conservation, particularly for widespread animals that influence ecosystem health and processes. Red foxes ( Vulpes vulpes ) are the most widely distributed mammalian carnivore globally, and provide many ecosystem services while also being a potential source of human‐wildlife conflict. Determining drivers of red fox distributions is therefore important for...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Polypharmacy and its association with dementia, Parkinson’s disease, and mortality risk in UK adults: a multistate modeling approachNARA Subscribed
Polypharmacy is common among older adults and has been linked to adverse outcomes such as dementia, Parkinson’s disease (PD), and mortality. However, its influence on transitions between these health states remains understudied in large, population-based cohorts. Using data from 361,970 UK Biobank participants aged 50 and older with up to 15 years of follow-up, we examined the association between polypharmacy, defined as the u...
Decorin Knockdown Improves Aged Tendon Healing by Enhancing Recovery of Viscoelastic Properties, While Biglycan May NotNARA Subscribed
The objective of the study was to determine the specific roles of decorin and biglycan in the early and late phases of tendon healing in aged mice. Aged (300 day-old) female wildtype (WT), Dcn flox/flox (I- Dcn -/- ), Bgn flox/flox (I- Bgn -/- ), and compound Dcn flox/flox /Bgn flox/flox (I- Dcn -/- /Bgn -/- ) mice with a tamoxifen (TM) inducible Cre underwent a bilateral patellar tendon injury (PT). Cre excision of the condit...
Plasma homocysteine level and trajectories in association with longitudinal increase in plasma neurofilament light among urban adultsNARA Subscribed
We tested whether homocysteine (Hcy) was linked to longitudinal change in plasma neurofilament light chain (NfL) overall and differentially across sex and race in a sample of middle-aged urban adults. We used data from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study [ n = 690, Age at visit 1 (v 1 :2004–2009): 30-66y, 42.1% male, 55.4% African American] to evaluate relationships between NfL l...
Uncovering mediational pathways behind racial and socioeconomic disparities in brain volumes: insights from the UK Biobank studyNARA Subscribed
Mediation pathways explaining racial/ethnic and socioeconomic (SES) disparities in structural MRI markers of brain health remain underexplored. We examined racial/ethnic and SES disparities in sMRI markers and tested total, direct, and indirect effects through lifestyle, health-related, and cognition factors using a structural equations modeling approach among 36,184 UK Biobank participants aged 40–70 years at baseline assessm...
Wind dispersed tree species have greater maximum heightNARA Subscribed
Aim We test the hypothesis that wind dispersal is more common among emergent tree species given that being tall increases the likelihood of effective seed dispersal. Location Americas, Africa and the Asia‐Pacific. Time period 1970–2020. Major taxa studied Gymnosperms and Angiosperms. Methods We used a dataset consisting of tree inventories from 2821 plots across three biogeographic regions (Americas, Africa and Asia‐Pacific),...
Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery OcclusionNARA Subscribed
Repulsive guidance molecule A (RGMa) is an inhibitor of neuronal growth and survival which is upregulated in the damaged central nervous system following acute spinal cord injury (SCI), traumatic brain injury, acute ischemic stroke (AIS), and other neuropathological conditions. Neutralization of RGMa is neuroprotective and promotes neuroplasticity in several preclinical models of neurodegeneration and injury including multiple...