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Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Quantifying 25 years of disease‐caused declines in Tasmanian devil populations: host density drives spatial pathogen spreadNARA Subscribed
Infectious diseases are strong drivers of wildlife population dynamics, however, empirical analyses from the early stages of pathogen emergence are rare. Tasmanian devil facial tumour disease (DFTD), discovered in 1996, provides the opportunity to study an epizootic from its inception. We use a pattern‐oriented diffusion simulation to model the spatial spread of DFTD across the species' range and quantify population effects by...
Regional variation in perceptions about climate changeNARA Subscribed
A 2007 survey covering rural areas in nine US states provides data on perceived local impacts of climate change. Perceptions vary from region to region, with a pattern suggesting links to real climate—specifically to winter warming in snow country. A multivariate analysis using mixed‐effects ordered logit regression confirms a significant perception‐temperature relationship, net of individual background and ideological charact...
Wintertime warming trends experienced in recent decades, and predicted to increase in the future, present serious challenges for ski areas and whole regions that depend on winter tourism. Most research on this topic examines past or future climate‐change impacts at yearly to decadal resolution, to obtain a perspective on climate‐change impacts. We focus instead on local‐scale impacts of climate variability, using detailed dail...
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