Background Tianeptine, an atypical antidepressant not approved in the United States, is readily purchased from unregulated markets such as the internet and gas stations. We became aware of a cluster of 34 patients in New Jersey who became ill following ingestion of the tianeptine containing-product Neptune’s Fix, the rate of which (4.6 cases per month) far exceeded the background rate for this substance of 0.5 cases per year....

The seasonal timing and magnitude of photosynthesis in evergreen needleleaf forests (ENFs) has major implications for the carbon cycle and is increasingly sensitive to changing climate. Earlier spring photosynthesis can increase carbon uptake over the growing season or cause early water reserve depletion that leads to premature cessation and increased carbon loss. Determining the start and the end of the growing season in ENFs...

2-Benzylbenzimidazole ‘nitazene’ opioids are presenting a growing threat to public health. Although various nitazenes were previously studied, systematic comparisons of the effects of different structural modifications to the 2-benzylbenzimidazole core structure on μ-opioid receptor (MOR) activity are limited. Here, we assessed in vitro structure–activity relationships of 9 previously uncharacterized nitazenes alongside known...

The crowns of juvenile Prumnopitys taxifolia (D. Don) de Laub. are comprised of thin, interlaced, wiry stems branching at wide angles and bearing sparse, scale‐like, clasping leaves (‘divaricating’ shoots) that generally surround stems bearing oblong, compressed leaves (‘leafy’ shoots). As development proceeds, non‐divaricating branches of the mature tree form exclusively; thus, P. taxifolia is profoundly heteroblastic. Divari...

To investigate if Eucalyptus species have responded to industrial‐age climate change, and how they may respond to a future climate, we measured growth and physiology of fast‐ ( E. saligna ) and slow‐growing ( E. sideroxylon ) seedlings exposed to preindustrial (290), current (400) or projected (650 μL L −1 ) CO 2 concentration ([CO 2 ]) and to current or projected (current +4 °C) temperature. To evaluate maximum potential trea...