Beckmann J results 36
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Formation and persistence of estragole-derived DNA adducts in human liver cells and tissueNARA Subscribed
Estragole (ES) is a phenylpropene naturally occurring in various herbs and spices, such as fennel and basil. Humans are exposed to ES via the diet or herbal medicinal products. Following its gastrointestinal resorption, hepatic bioactivation of ES by Cytochrome P450 monooxygenases (CYPs) and sulfotransferases (SULTs) can lead to DNA adduct formation and liver cancer in rodents. Up to now, no data is available on ES-dependent D...
Haptoglobin Attenuates Cerebrospinal Fluid Hemoglobin-Induced Neurological Deterioration in SheepNARA Subscribed
Secondary brain injury (SBI) occurs with a lag of several days post-bleeding in patients with aneurysmal subarachnoid hemorrhage (aSAH) and is a strong contributor to mortality and long-term morbidity. aSAH-SBI coincides with cell-free hemoglobin (Hb) release into the cerebrospinal fluid. This temporal association and convincing pathophysiological concepts suggest that CSF-Hb could be a targetable trigger of SBI. However, spar...
Functional and vascular neuroimaging in maritime pilots with long-term sleep disruptionNARA Subscribed
The mechanism underlying the possible causal association between long-term sleep disruption and Alzheimer’s disease remains unclear Musiek et al. 2015. A hypothesised pathway through increased brain amyloid load was not confirmed in previous work in our cohort of maritime pilots with long-term work-related sleep disruption Thomas et al. Alzheimer’s Res Ther 2020;12:101. Here, using functional MRI, T2-FLAIR, and arterial spin l...
Main conclusion Salinity induced metabolite responses resulted in differential accumulation of flavonoids and antioxidant metabolites in shoots and roots suggesting improved antioxidant capacity in providing salt-adaptive phenotype of tef seedling. Abstract Tef [( Eragrostis tef ) (Zucc.) Trotter] is an important ‘cash crop’ of Ethiopia grown mainly for human food, and development of elite tef cultivars with better performance...
Weak evidence that asset protection underlies temporal or contextual consistency in boldness of a terrestrial crustaceanNARA Subscribed
In recent years, many studies have investigated the potential state dependence of individual differences in behaviour, with the aim to understand the proximate and ultimate causes and consequences of animal personality. Among the potential state variables that could affect behavioural expression is size and mass, but few studies have found associations at the among-individual levels. Insufficient sampling and incorrect analysi...
Sperm whales exhibit variation in echolocation tactics with depth and sea state but not naval sonar exposuresNARA Subscribed
Auditory masking by anthropogenic noise may impact marine mammals relying on sound for important life functions, including echolocation. Animals have evolved antimasking strategies, but they may not be completely effective or cost‐free. We formulated seven a priori hypotheses on how odontocete echolocation behavior could indicate masking. We addressed six of them using data from 15 tagged sperm whales subject to experimental e...
An apex carnivore’s life history mediates a predator cascadeNARA Subscribed
TRY plant trait database – enhanced coverage and open accessNARA Subscribed
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodivers...
Plasticity in elk migration timing is a response to changing environmental conditionsNARA Subscribed
Migration is an effective behavioral strategy for prolonging access to seasonal resources and may be a resilient strategy for ungulates experiencing changing climatic conditions. In the Greater Yellowstone Ecosystem ( GYE ), elk are the primary ungulate, with approximately 20,000 individuals migrating to exploit seasonal gradients in forage while also avoiding energetically costly snow conditions. How climate‐induced changes i...
Exophiala angulospora infection in hatchery‐reared lumpfish ( Cyclopterus lumpus ) broodstockNARA Subscribed
Samples from moribund lumpfish were collected in a marine hatchery in Scotland in 2015. Black nodules were noted on the skin, and gills and fungal hyphae were extensively distributed in musculature and internal organs. Multifocal chronic inflammatory lesions displaced structures in all affected organs. Mortalities commenced on completion of spawning in May and were evenly distributed over the second year in the temperature ran...