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Water table fluctuations regulate the transformation and fate of nitrogen (N) species in groundwater near streams, particularly in Mediterranean catchments with dry conditions interrupted by wet seasons. To understand N dynamics at the interface between soils and groundwater, a 1-m-long soil column was constructed and filled with riparian soil with elevated organic matter content, retrieved from an experimental site in Font de...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Forest Heterogeneity by Chain Saw: How Between‐Patch Variation in Old Growth Attributes Changes the Metacommunities of BeetlesNARA Subscribed
Metacommunity theory has expanded our understanding of how spatial dynamics and local interactions influence species communities. Different assembly archetypes, reflecting different roles of species differences, habitat differences, and dispersal have been described, but we lack empirical studies specifically in terrestrial habitats testing which archetype is most important. In a replicated design, we experimentally enhanced s...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Plastic pollution has become increasingly apparent in sandy beach zones and aquatic environments, creating more than just visual pollution. Impacts are observed in many environmental and social levels, including the fishing communities that depend on the coastal environment for their livelihoods. Plastic pollution was assessed on the sandy beaches and mangroves of Ghana’s Western and Central regions. The study’s objective was...
The ocean, a pivotal component of the Earth’s climate system, exerts a profound global influence through intricate physical and biological interactions within its surface layer. This interplay centers around the mixed layer (ML), integral for energy exchange driven by oceanic currents. An essential regulatory function of the ocean involves orchestrating the distribution of chemical elements, with nitrate assuming a pivotal rol...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
In this study, we explored the effects of chronic stress on lumpfish ( Cyclopterus lumpus ) physiological, immune response, health, and plasma free amino acids. 3 groups of lumpfish were exposed to 1-minute air exposure. 1 group was exposed to stress once per week, a second group exposed 2 times per week, and a third group exposed 4 times per week. The present study revealed significant alterations in immunity and increased nu...
Institution-Wide Retreats Foster Organizational Learning and Action at a Comprehensive Cancer CenterNARA Subscribed
Providing safe and informed healthcare for sexual and gender minority (SGM) individuals with cancer is stymied by the lack of sexual orientation and gender identity (SOGI) data reliably available in health records and by insufficient training for staff. Approaches that support institutional learning, especially around sensitive topics, are essential for hospitals seeking to improve practices impacting patient safety and resear...
What makes a habitat a home? Habitat associations of juvenile European sea bass, Dicentrarchus labrax , in estuarine nurseriesNARA Subscribed
Selection of nursery habitats by marine fish, such as European sea bass ( Dicentrarchus labrax ), is poorly understood. Identifying and protecting the full range of juvenile nursery habitats is vital to supporting resilient fish populations and economically important fisheries. We examined how the condition, stomach fullness, and diet of juvenile European sea bass, along with their abundance, differ at high or low tide between...
Rubble persistence under ocean acidification threatened by accelerated bioerosion and lower‐density coral skeletonsNARA Subscribed
As the balance between erosional and constructive processes on coral reefs tilts in favor of framework loss under human‐induced local and global change, many reef habitats worldwide degrade and flatten. The resultant generation of coral rubble and the beds they form can have lasting effects on reef communities and structural complexity, threatening the continuity of reef ecological functions and the services they provide. To c...
Pathways from research to sustainable development: Insights from ten research projects in sustainability and resilienceNARA Subscribed
Drawing on collective experience from ten collaborative research projects focused on the Global South, we identify three major challenges that impede the translation of research on sustainability and resilience into better-informed choices by individuals and policy-makers that in turn can support transformation to a sustainable future. The three challenges comprise: (i) converting knowledge produced during research projects in...
Systematic distributions of interaction strengths across tree interaction networks yield positive diversity–productivity relationshipsNARA Subscribed
Understanding the mechanisms underlying diversity–productivity relationships (DPRs) is crucial to mitigating the effects of forest biodiversity loss. Tree–tree interactions in diverse communities are fundamental in driving growth rates, potentially shaping the emergent DPRs, yet remain poorly explored. Here, using data from a large‐scale forest biodiversity experiment in subtropical China, we demonstrated that changes in indiv...
The Toxicology Investigators Consortium 2022 Annual ReportNARA Subscribed