Benjamin FitzGerald results 13
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Cellular and Extracellular MicroRNA Dysregulation in LRRK2-Linked Parkinson’s DiseaseNARA Subscribed
Cell-free microRNAs in body fluids have emerged as promising biomarker candidates in neurodegenerative diseases. While several studies have identified dysregulated miRNAs in sporadic Parkinson’s disease, it remains unclear whether distinguishable alterations of cell-free miRNAs occur in genetic forms of the disease, such as those associated with the LRRK2 G2019S mutation. In this proof-of-concept study, we used a human induced...
Global food production, both aquatic and terrestrial, is rife with sustainability issues. Aquaculture is a rapidly growing industry that is on track to surpass wild-caught fishery production by 2030. The integration of aquaculture and agriculture systems could help to reduce some of their respective and shared environmental issues. Integrated Aquaculture–Agriculture (IAA) has been shown to provide a variety of benefits to both...
The rapid increase in aquaculture over the last several decades has led to concerns about the environmental impact of fish feeds relying on marine resources for fishmeal (FM). We aim to assess Nannochloropsis sp. QH25 co-product as a viable and sustainable replacement for FM in juvenile rainbow trout, Oncorhynchus mykiss , feeds. We formulated four experimental diets: a reference (FM based), 33N, 66N, and 100N diet (33%, 66%,...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Quantifying thermal exposure for migratory riverine species: Phenology of Chinook salmon populations predicts thermal stressNARA Subscribed
Migratory species are particularly vulnerable to climate change because habitat throughout their entire migration cycle must be suitable for the species to persist. For migratory species in rivers, predicting climate change impacts is especially difficult because there is a lack of spatially continuous and seasonally varying stream temperature data, habitat conditions can vary for an individual throughout its life cycle, and v...
Climate change impact and adaptation for wheat proteinNARA Subscribed
Wheat grain protein concentration is an important determinant of wheat quality for human nutrition that is often overlooked in efforts to improve crop production. We tested and applied a 32‐multi‐model ensemble to simulate global wheat yield and quality in a changing climate. Potential benefits of elevated atmospheric CO 2 concentration by 2050 on global wheat grain and protein yield are likely to be negated by impacts from ri...
A recent innovation in assessment of climate change impact on agricultural production has been to use crop multimodel ensembles ( MME s). These studies usually find large variability between individual models but that the ensemble mean (e‐mean) and median (e‐median) often seem to predict quite well. However, few studies have specifically been concerned with the predictive quality of those ensemble predictors. We ask what is th...
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