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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Larval Arctic cod ( Boreogadus saida ) exhibit stronger developmental and physiological responses to temperature than to elevated pCO 2NARA Subscribed
High‐latitude ecosystems are simultaneously warming and acidifying under ongoing climate change. Arctic cod ( Boreogadus saida ) are a key species in the Arctic Ocean and have demonstrated sensitivity to ocean warming and acidification as adults and embryos, but their larval sensitivity to the combined stressors is unknown. In a laboratory multi‐stressor experiment, larval Arctic cod were exposed to a combination of three temp...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
The combined effects of ocean warming and ocean acidification on Pacific cod (Gadus macrocephalus) early life stagesNARA Subscribed
The eastern North Pacific is simultaneously experiencing ocean warming (OW) and ocean acidification (OA), which may negatively affect fish early life stages. Pacific cod ( Gadus macrocephalus ) is an economically and ecologically important species with demonstrated sensitivity to OW and OA, but their combined impacts are unknown. Through a ~ 9-week experiment, Pacific cod embryos and larvae were reared at one of six combinatio...
Pacific cod in the Anthropocene: An early life history perspective under changing thermal habitatsNARA Subscribed
The rapid decline in Pacific cod ( Gadus macrocephalus , Gadidae) biomass following multiple Gulf of Alaska marine heatwaves (2014–2016 and 2019) may be one of the most dramatic documented changes in a sustainably managed marine fishery. As such, fisheries managers are exploring new recruitment paradigms for Pacific cod under novel environmental conditions. In this review, we address the challenges of managing and forecasting...
Quantifying the spatial and temporal footprint of multiple environmental stressors on marine fisheries is imperative to understanding the effects of changing ocean conditions on living marine resources. Pacific Cod (Gadus macrocephalus) , an important marine species in the Gulf of Alaska ecosystem, has declined dramatically in recent years, likely in response to extreme environmental variability in the Gulf of Alaska related t...
Multiple aspects of climate change are expected to co‐occur such that ocean acidification will take place in conjunction with warming and a range of trophic changes. Previous studies have demonstrated that nutritional condition plays a significant role in the responses of invertebrates to ocean acidification, but similar studies have yet to be conducted with marine fishes. In this study, we examined the potential interactive e...
The effects of temperature on growth, development and settlement of northern rock sole larvae ( L epidopsetta polyxystra )NARA Subscribed
Northern rock sole ( L epidopsetta polyxystra ) is a commercially important fish in the N orth P acific and a focal species in understanding larval transport to nursery grounds in the B ering S ea. However, the temperature‐dependent vital rates and settlement dynamics for this species have not been described in detail. We reared northern rock sole larvae in the laboratory to measure growth, condition, development and settlemen...
Effects of ontogeny, temperature, and light on vertical movements of larval Pacific cod ( Gadus macrocephalus )NARA Subscribed
The role of behavior, especially vertical migration, is recognized as a critical component of realistic models of larval fish dispersion. Unfortunately, our understanding of these behaviors lags well behind our ability to construct three‐dimensional flow‐field models. Previous field studies of vertical behavior of larval Pacific cod ( Gadus macrocephalus ) were limited to small, preflexion stages (≤11 mm SL) in a narrow range...
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