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Impact of Neutrophil Extracellular Traps on Clinical Outcome after Subarachnoid Hemorrhage: A Translational Narrative ReviewNARA Subscribed
Aneurysmal subarachnoid hemorrhage (aSAH) remains associated with substantial morbidity and mortality despite best medical treatment. Increasing evidence implicates thrombo-inflammation (TI), driven by neutrophils and neutrophil extracellular traps (NETs), in the pathogenesis of delayed cerebral ischemia (DCI) and cognitive impairment. This narrative review summarizes experimental and clinical data linking neutrophil activatio...
This study sought to evaluate the characteristics of clinical-pharmacological (CP) medication reviews conducted by the Institute for Clinical Pharmacology of Hannover Medical School for older, multimorbid, polymedicated insurants of the German statutory health insurance fund Kaufmännische Krankenkasse (KKH). Special emphasis was put on potential sex-specific differences between female and male insurants, prescriptions of poten...
A primary care pharmacogenetic precision medicine pilot based on specific Māori tribal ethical frameworks and principlesNARA Subscribed
Indigenous tribal communities are frequently underserved by genomic medicine because they are under-represented in research, often live in remote locations and have ethical and cultural perspectives that vary from westernised standpoints. The Rakeiora platform, a permissioning and analytical environment that incorporates Māori perspectives and ethical frameworks on how precision medicine research is best conducted was used to...
The hyperiid amphipod Brachyscelus rapacoides is a warm-water species associated with gelatinous zooplankton. In the Mediterranean it has been reported in association with Rhopilema nomadica in both Israel and Turkey. Here, we document the first record of B. rapacoides in Greek waters, representing the first confirmed record for Europe, based on both morphological examination and DNA barcoding of the mitochondrial COI gene. Sp...
Escherichia coli ( E. coli ) ST131 is a multidrug-resistant pandemic clone of extended-spectrum beta-lactamase-producing bacteria, with the primary reservoir within the gut. A biotherapeutic strategy to limit the intestinal carriage of ST131 E. coli isolates has been developed using a modified version of the probiotic E. coli strain Nissle 1917 (EcN 2.0) that does not exhibit genotoxic activity and overexpresses microcins. The...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Forest Heterogeneity by Chain Saw: How Between‐Patch Variation in Old Growth Attributes Changes the Metacommunities of BeetlesNARA Subscribed
Metacommunity theory has expanded our understanding of how spatial dynamics and local interactions influence species communities. Different assembly archetypes, reflecting different roles of species differences, habitat differences, and dispersal have been described, but we lack empirical studies specifically in terrestrial habitats testing which archetype is most important. In a replicated design, we experimentally enhanced s...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...