Benjamin Wilson results 95
· Newest (Page 1/4, per page 25)
Author: Benjamin Wilson ×Clear All Filters
Search Results
Despite extensive research on the western Pacific crown-of-thorns starfish (CoTS; Acanthaster cf. solaris ), especially from Australia’s Great Barrier Reef (GBR), there are persistent knowledge gaps that constrain understanding and management. Given renewed population irruptions of CoTS on the GBR, alongside escalating climate impacts and direct anthropogenic pressures, a quantitative assessment of knowledge gaps was undertake...
The hyperiid amphipod Brachyscelus rapacoides is a warm-water species associated with gelatinous zooplankton. In the Mediterranean it has been reported in association with Rhopilema nomadica in both Israel and Turkey. Here, we document the first record of B. rapacoides in Greek waters, representing the first confirmed record for Europe, based on both morphological examination and DNA barcoding of the mitochondrial COI gene. Sp...
Although plasma pTau181 has been shown to accurately discriminate patients with Alzheimer’s disease from healthy older adults, there are few studies of plasma biomarkers among middle-aged populations. Given the potential utility of plasma AD biomarkers such as pTau181 in screening for disease risk, examining pTau181 in a middle-aged cohort without AD is important for future implementation. The objectives of this study were to...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Salinity gradients and fluctuations can create a natural ecological filter, with few species tolerating salinity above 50 practical salinity units (PSUs). We investigated how an inverse salinity gradient affected marine community diversity and composition in Shark Bay, a remote hypersaline coastal embayment in Western Australia. We used 16S(fish), 18S and 16S(Bacteria) eDNA metabarcoding assays to analyse genetic sequences col...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Locally Reprogramming Tumor-Associated Macrophages with Cytokine-Loaded Injectable Cryogels for Breast CancerNARA Subscribed
Purpose Tumor-associated macrophages (TAMs) are the most abundant immune cells in primary solid tumors, including breast cancer, and typically exhibit an M2-like, immunosuppressive phenotype that promotes tumor growth. Given that TAMs can be repolarized through cytokine signaling, we propose a localized cytokine delivery depot using an injectable alginate cryogel to reprogram TAMs and create an inflammatory, anti-tumor TME. Me...
Climate change and local pressures are eroding the health and performance of many watersheds and their freshwater ecosystems, pushing these complex social‐ecological systems to the boundaries of their safe operating space. Here, we offer a synthetic perspective on the downscaled application of the safe operating space concept to inform the stewardship of watersheds in this time of rapid climate change, with particular focus on...