Benjamin Wu results 112
· Newest (Page 1/5, per page 25)
Author: Benjamin Wu ×Clear All Filters
Search Results
Missing hills affect the yield of a single plant in experimental plots, as the remaining plants have more space and resources compared to plants in plots without missing hills. However, up to date, no universal way on how to correct for missing hills exists in the context of potato breeding programs. The aim of our study was to (i) compare different approaches to adjust the yield when hills are missing in a plot, (ii) propose...
Bridging tradition and innovation: a review of computer simulations in plant breedingNARA Subscribed
The wide range of tools and methods available to plant breeders today has the potential to increase the gain of selection. However, they also result in numerous complex choices in the design of efficient crossing and selection strategies. Computer simulations are essential to optimize breeding programs that are multi-year, high-effort endeavors and to compare process efficiencies without going through field experiments, thus s...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Docosahexaenoic acid supplementation inhibits monocyte exhaustion memory formation during sepsisNARA Subscribed
Objective and design Docosahexaenoic acid (DHA) is an omega-3 fatty acid with important roles in inflammation resolution. We tested the impact of DHA supplementation on monocyte exhaustion, an immune memory state contributing to chronic inflammation and immunosuppression following sepsis. Materials or subjects Ex vivo sepsis modeling was performed with C57BL/6 mouse bone marrow monocytes (BMMCs) and peripheral blood mononuclea...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Winter torpor and body mass patterns of a cave-roosting bat in cool and warm climatesNARA Subscribed
Torpor is an important energy-saving strategy for small insectivorous bats during winter. White-nose syndrome (WNS), a fungal disease affecting hibernating bats, disrupts torpor-arousal patterns and increases energy use, leading to higher winter mortality. In North America, WNS has also infected bats in milder southern climates, supporting concerns about potential impacts if introduced to the Southern Hemisphere. To understand...
Technical Considerations of Pharmacokinetic Assays for LNP-mRNA Drug Products by RT-qPCRNARA Subscribed
Lipid nanoparticle-messenger RNA (LNP-mRNA) drug products are a growing class of drug modalities. The unique composition of these drug products requires multiple measurements to account for the different components of these drug modalities. Pharmacokinetic (PK) measurements include measurement of the encapsulated mRNA and components of the LNP in circulation to understand the effectiveness of the therapeutic mRNA. The PK measu...