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European Journal of Clinical Pharmacology · 2024 · Vol. 80 · Issue 9 · Springer
Purpose Currently, body weight-based dosing of rifampicin is recommended. But lately, fat-free mass (FFM) was reported to be superior to body weight (BW). The present evaluation aimed to assess the influence of body mass-related covariates on rifampicin’s pharmacokinetics (PK) parameters in more detail using non-linear mixed effects modeling (NLMEM). Methods Twenty-four healthy Caucasian volunteers were enrolled in a bioequiva...