Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) cultured in the presence of retinoic acid were proposed as a model for human atrium. Since in the human heart positive inotropic effects of serotonin (5-HT) are restricted to the atrium, we investigated whether the presence of 5-HT responses may distinguish between hiPSC-atrial and ventricular CM. Nonfiltered retinoic acid (1 µM) was used to induce an atrial...

Grazing by sea urchins is a main driver of kelp forest dynamics causing shifts from kelp forests to urchin barrens in the temperate region but there is limited information on such patterns from the Arctic region. Based on information from 132 underwater video transects along Greenland's West Coast at 59.9–77.8°N, we explored the distribution of kelps and sea urchins, including the occurrence of sea urchin barrens, along latitu...

Forest ecosystems are of global importance, ecologically, economically and culturally. However, despite their fundamental role in mitigating the worst effects of climate change, to date there have been surprisingly few resources devoted to defining, conserving and planning resilient forests for the future. Progress in this field of research, which requires international and interdisciplinary cooperation, collaboration and comm...

Dissolved and particulate organic carbon (DOC, POC) and nitrogen (DON, PON) constitute essential nutrient and energy sources to heterotrophic microbes in aquatic systems. Especially in the shallow coastal ocean, the concentrations are highly variable on short timescales, and cycling is heavily affected by different sources and environmental drivers. We analyzed surface water organic carbon and nitrogen concentrations determine...