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Springer Nature1
Journal
Drug Delivery and Translational Research1
Publication Year
20211
Birgit Nothdurft results 1 · Newest (Page 1/1, per page 25)
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Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticalsNARA Subscribed
Drug Delivery and Translational Research · 2021 · Vol. 11 · Issue 4 · Springer
Durairaj Thiyagarajan; Benedikt Huck; Birgit Nothdurft; Marcus Koch; David Rudolph; Mark Rutschmann; Claus Feldmann; Constantin Hozsa; Marcus Furch; Karen F. W. Besecke; Robert K. Gieseler; Brigitta Loretz; Claus-Michael Lehr
Pulmonary delivery of nanocarriers for novel antimycobacterial compounds is challenging because the aerodynamic properties of nanomaterials are sub-optimal for such purposes. Here, we report the development of dry powder formulations for nanocarriers containing benzothiazinone 043 (BTZ) or levofloxacin (LVX), respectively. The intricacy is to generate dry powder aerosols with adequate aerodynamic properties while maintaining b...
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