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Advances in Traditional Medicine · 2025 · Vol. 26 · Issue 3 · Springer
In the current work, we investigated the antitumor effects of a 30% ethanol extract of chili pepper leaves ( Capsicum annum; PLE), in Hep3B and Huh7 hepatocellular carcinoma (HCC) cells. PLE showed significant cytotoxicity and reduced the expression of pro-caspase 3 and pro-poly (ADP-ribose) polymerase (pro-PARP) in Hep3B and Huh7 cells. Also, it also suppressed glycolysis-related proteins, including hexokinase 2 (HK2), pyruva...