Brett R. Riddle results 13
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Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Genetic consequences of postglacial range expansion in two codistributed rodents (genus Dipodomys ) depend on ecology and genetic locusNARA Subscribed
How does range expansion affect genetic diversity in species with different ecologies, and do different types of genetic markers lead to different conclusions? We addressed these questions by assessing the genetic consequences of postglacial range expansion using mitochondrial DNA (mt DNA ) and nuclear restriction site‐associated DNA ( RAD ) sequencing in two congeneric and codistributed rodents with different ecological chara...
Aim As data accumulate, a multi‐taxon biogeographical synthesis of the M ojave D esert is beginning to emerge. The initial synthesis, which we call the ‘ M ojave A ssembly M odel’, was predominantly based on comparisons of phylogeographical patterns from vertebrate taxa. We tested the predictions of this model by examining the phylogeographical history of H adrurus arizonensis , a large scorpion from the M ojave and S onoran d...
FrontispieceNARA Subscribed
We are currently experiencing a resurgence of interest in ecogeographical rules, which describe general trends in morphology and related traits along geographical gradients. In order to develop a more comprehensive understanding of the generality and underlying causal mechanisms for these patterns, we recommend a new, more integrated research agenda. In particular, we recommend studies that simultaneously consider different cl...
We define the geographical distributions of mitochondrial DNA (mtDNA) lineages embedded within a broadly distributed, arid‐dwelling toad, Bufo punctatus . These patterns were evaluated as they relate to hypothesized vicariant events leading to the formation of desert biotas within western North America. We assessed mtDNA sequence variation among 191 samples from 82 sites located throughout much of the species’ range. Parsimony...
Ploidy race distributions since the Last Glacial Maximum in the North American desert shrub, Larrea tridentataNARA Subscribed
A classic biogeographic pattern is the alignment of diploid, tetraploid and hexaploid races of creosote bush ( Larrea tridentata ) across the Chihuahuan, Sonoran and Mohave Deserts of western North America. We used statistically robust differences in guard cell size of modern plants and fossil leaves from packrat middens to map current and past distributions of these ploidy races since the Last Glacial Maximum (LGM). Glacial/e...
Species as units of analysis in ecology and biogeography: time to take the blinders offNARA Subscribed
Summary Species and their geographical distributions, tabulated either from regional faunal and floral monographs or directly from natural history collections, often are used as the basic units of analysis by ecologists and biogeographers. It has been argued that in order for species to be operationally useful units for evolutionary and ecological studies, they need to be recognizable and identifiable as distinct entities. A g...
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