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A Quantitative Approach to Guiding Target Antigen Selection and Antibody Optimization in Recycling Antibody DiscoveryNARA Subscribed
Recycling antibodies can enhance therapeutic efficacy by enabling efficient antigen removal through pH-dependent binding mechanisms enabling antibody recycling, but the optimal targets for this strategy remain unclear. This work employs a mathematical modeling approach using a minimal PBPK model, along with global and local sensitivity analyses, to explore how target turnover rates influence the suitability of recycling antibo...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Remotely Sensed Fire Heterogeneity and Biomass Recovery Predicts Empirical Biodiversity ResponsesNARA Subscribed
Aim To compare field‐based evidence of plant and animal responses to fire with remotely sensed signals of fire heterogeneity and post‐fire biomass recovery. Location South‐eastern Australia; New South Wales. Time Period 2019–2022. Major Taxa Studied A total of 982 species of plants and animals, in eight taxonomic groups: amphibians, birds, fish, insects, mammals, molluscs, plants and reptiles. Methods We collated 545,223 plant...
Data capturing multiple axes of tree size and shape, such as a tree's stem diameter, height and crown size, underpin a wide range of ecological research—from developing and testing theory on forest structure and dynamics, to estimating forest carbon stocks and their uncertainties, and integrating remote sensing imagery into forest monitoring programmes. However, these data can be surprisingly hard to come by, particularly for...
Our ability to completely and repeatedly map natural environments at a global scale have increased significantly over the past decade. These advances are from delivery of a range of on-line global satellite image archives and global-scale processing capabilities, along with improved spatial and temporal resolution satellite imagery. The ability to accurately train and validate these global scale-mapping programs from what we w...
Loss and damage from climate change and implicit assumptions of sustainable developmentNARA Subscribed
Loss and damage from climate change, recognized as a unique research and policy domain through the Warsaw International Mechanism (WIM) in 2013, has drawn increasing attention among climate scientists and policy makers. Labelled by some as the “third pillar” of the international climate regime—along with mitigation and adaptation—it has been suggested that loss and damage has the potential to catalyze important synergies with...
Assessing life cycle impacts from changes in agricultural practices of crop productionNARA Subscribed
Purpose This paper presents an improved methodological approach for studying life cycle impacts (especially global warming) from changes in crop production practices. The paper seeks to improve the quantitative assessment via better tools and it seeks to break down results in categories that are logically separate and thereby easy to explain to farmers and other relevant stakeholder groups. The methodological framework is illu...
Exploring potential establishment of marine rafting species after transoceanic long‐distance dispersalNARA Subscribed
Aim On 11 March 2011, the Great East Japan Earthquake triggered a massive tsunami that resulted in the largest known rafting event in recorded history. By spring 2012, marine debris began washing ashore along the Pacific coast of the United States and Canada with a wide range of Asian coastal species attached. We used this unique dataset, where the source region, date of dislodgment and landing location are known, to assess th...
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