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NARA Subscribed1
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Springer Nature1
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GeroScience1
Publication Year
20251
Bruce Ziman results 1 · Newest (Page 1/1, per page 25)
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Angiotensin II, miR-34a, and AGTRAP crosstalk in arterial smooth muscle cellsNARA Subscribed
GeroScience · 2025 · Vol. 48 · Issue 1 · Springer
Maria Cristina Florio; Sara Sileno; Liqun Jiang; Marco D’Agostino; Sunayana Begum Syed; Laura Monteonofrio; Mirko Baranzini; Chiara Prampolini; Federica Macrì; Manuel Casaburo; Nadia Fanotti; Stefania Castiglione; Robert E. Monticone; Bruce Ziman; Richard Telljohann; Mingyi Wang; Julie A. Mattison; Christopher H. Morrell; Angela Raucci; Edward G. Lakatta; Alessandra Magenta; Maurizio Colognesi-Capogrossi
Arterial aging is associated with enhanced angiotensin II (Ang II) signaling via Ang II type 1 receptor (AT1R) and with microRNA-34a (miR-34a) increased expression. AT1R-associated protein (ATRAP/Agtrap) binds to AT1R, promotes its internalization, and inhibits Ang II signaling. This study addresses the hypothesis that miR-34a targets ATRAP/Agtrap and enhances Ang II pro-inflammatory signaling via AT1R in arterial vascular smo...
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