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NARA Subscribed1
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Wiley1
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Environmental Microbiology1
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20021
Bryce P. Nelson results 1 · Newest (Page 1/1, per page 25)
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Label‐free detection of 16S ribosomal RNA hybridization on reusable DNA arrays using surface plasmon resonance imagingNARA Subscribed
Environmental Microbiology · 2002 · Vol. 4 · Issue 11 · Wiley
Bryce P. Nelson; Mark R. Liles; Kendra B. Frederick; Robert M. Corn; Robert M. Goodman
Summary In this paper, we describe the detection of bacterial cell‐extracted 16S ribosomal RNA (rRNA) using an emerging technology, surface plasmon resonance (SPR) imaging of DNA arrays. Surface plasmon resonance enables detection of molecular interactions on surfaces in response to changes in the index of refraction, therefore eliminating the need for a fluorescent or radioactive label. A variation of the more common SPR tech...
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