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Regulation of PDGF-BB signaling in placental pericytes by soluble PDGFRβ isoforms: implications for fetoplacental vascular developmentNARA Subscribed
Vascular remodeling within the developing fetus and placenta is essential for supporting the growth and function of emerging tissues and organs. Pericytes (PCs) play a central role in stabilizing and maturing microvascular networks by extending along endothelial cells (ECs) and reinforcing vessel integrity. In the placenta, as in other organs, PC–EC communication is mediated in part by platelet-derived growth factor-BB (PDGF‑B...
High‐Throughput Sequencing in Aquaculture Disease Investigations: Challenges and Opportunities for ImplementationNARA Subscribed
The current generation of sequencing technologies can produce terabases of data with exceptional accuracy and speed, at a fraction of the cost of older methods. Despite this unprecedented power, adoption into aquaculture health management presents several challenges, including identifying where such capability may be optimally deployed. Here we synthesise discussions from a structured expert workshop held at the 2025 Aotearoa...
Divergence in migratory behaviour represents a striking and common axis of life‐history variation in animals. Plastic changes in adult animals in preparation for migration are well known, but the differences in early development between migratory and non‐migratory forms are not well documented. These differences might contribute to reproductive isolation because of the potentially substantial divergence in metabolism and physi...
Transition to fetal calf serum-free culture enhances kidney proximal tubule cell bioenergetics and allows pharmacological applicationsNARA Subscribed
Proximal tubule in vitro systems are important tools in pre-clinical drug development, providing insights into drug disposition and safety. Cells are often cultured in medium containing fetal calf serum (FCS); however, FCS addition is not physiologically relevant for cells of human origin. Here, in vitro cultures of human kidney proximal tubule cells were transitioned to FCS-free medium. The impact of FCS-free medium on matura...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Cold storage of alarm substance reduces the behavioural stress response of zebrafish ( Danio rerio )NARA Subscribed
Alarm substance (AS) is widely used in zebrafish ( Danio rerio , Hamilton, 1822) antipredator research to elicit an alarm reaction. This alarm reaction consists of stereotypical behaviours, including freezing, erratic swimming and a tendency to dwell at the bottom of the tank (geotaxis). Because the active compound in AS is known to degrade rapidly, many investigators choose to freeze AS until use, whereas others argue for col...
Diversity and distribution of Lophodermium species on non-native Pinus species in the Southern HemisphereNARA Subscribed
Lophodermium species are amongst the most commonly isolated endophytic fungi on the needles and cones of pines. Of the 38 species reported on these trees, only Lophodermium seditiosum is considered a major pathogen. Species of Pinus have been widely established as non-natives in Southern Hemisphere countries, and several Lophodermium species have been reported on the needles of these trees. However, most of these reports are b...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...