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Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Iron and nitrogen stress controls summertime biogeochemistry in the high‐latitude North AtlanticNARA Subscribed
High‐latitude North Atlantic currents (60°–70°N) exhibit contrasting nutrient stoichiometries, but the spatial extent of post‐spring bloom iron (Fe) and nitrogen (N) stress on phytoplankton around Iceland remains poorly constrained. Here we pair in situ biogeochemical characteristics with 72 h Fe and N addition experiments in the East Greenland Current (EGC), Irminger Current (IC), Atlantic Current (AC), and East Icelandic Cur...
The brain endocast of the Canary Islands giant rats (Canariomys, Muridae, Rodentia): paleobiological and evolutionary implicationsNARA Subscribed
Insular mammal faunas have been the focus of numerous studies in evolutionary biology, specifically regarding the patterns of dwarfism and gigantism. Previous work has shown either increase or decrease in relative brain size in various clades, including elephants, hippos, lagomorphs, bovids, and multituberculates. Decrease in specific senses such as audition and vision were also observed. In this study, we describe the virtual...
MACROSISDATA: safeguarding and promoting the heritage of French macroseismic surveys carried out between 1921 and 1996NARA Subscribed
Macroseismic surveys are of great interest to both the scientific community and the authorities.The aim of the MACROSISDATA project is to safeguard, disseminate, and promote through an online database the macroseismic survey documents collected by the French Central Seismological Bureau between 1921 and 1996. During this period, a total of 1428 earthquakes were surveyed to estimate macroseismic intensities (severity of ground...
Motivation Pollinators play a crucial role in maintaining Earth's terrestrial biodiversity. However, rapid human‐induced environmental changes are compromising the long‐term persistence of plant‐pollinator interactions. Unfortunately, we lack robust, generalisable data capturing how plant‐pollinator communities are structured across space and time. Here, we present the EuPPollNet (European Plant‐Pollinator Networks) database,...
Beyond Huntington’s Disease – Late-Onset Chorea Caused by a Homozygous Variant in ERCC4NARA Subscribed
Genetic alterations in the ERCC4 gene typically cause Xeroderma pigmentosum and other nucleotide excision repair disorders. Neurologic symptoms are present in some of these patients. In rare cases, ERCC4 -mutations can manifest with prominent neurologic symptoms. We report a 62-year-old woman who presented with a movement disorder caused by a homozygous pathogenic variant in the ERCC4 gene. She presented with a hyperkinetic mo...
Production and utilization of pseudocobalamin in marine Synechococcus cultures and communitiesNARA Subscribed
Cobalamin influences marine microbial communities because an exogenous source is required by most eukaryotic phytoplankton, and demand can exceed supply. Pseudocobalamin is a cobalamin analogue produced and used by most cyanobacteria but is not directly available to eukaryotic phytoplankton. Some microbes can remodel pseudocobalamin into cobalamin, but a scarcity of pseudocobalamin measurements impedes our ability to evaluate...