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Targeting Mitochondrial Dysfunction in Acute Organophosphate Toxicity: A Preliminary Evaluation of Cyclosporine ANARA Subscribed
Background Organophosphate (OP) compounds are widely used agricultural chemicals that pose significant public health and chemical threat concerns due to their neurotoxic effects. Although OP toxicity has classically been attributed to acetylcholinesterase inhibition and cholinergic crisis, emerging evidence suggests mitochondrial dysfunction may represent an additional and clinically relevant mechanism of injury. Experimental...
Outbreaks of western Pacific crown-of-thorns sea stars (CoTS, Acanthaster cf. solaris ) remain one of the foremost contributors to coral loss on Australia’s Great Barrier Reef. For CoTS to reach maturity, juveniles feeding on crustose coralline algae (CCA) must complete an ontogenetic diet shift to reef-building corals. Here, we tested whether four different diets of CCA fed to herbivorous juveniles over 12 weeks influence the...
Experiences Applying a DIY Wireless Wind Data Acquisition System in Coastal Dune Field StudiesOA Marine
Coastal dune fields and other coastal arid environments are dynamic ecosystems that provide a wide range of functions and services, many still insufficiently understood, and are of particular importance amid ongoing global change and increasing anthropogenic pressure. In this paper, we present our experience applying a DIY wireless wind data-acquisition system across six coastal dune-field studies covering diverse applications...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Tropical Montane Cloud Forests Have High Resilience to Five Years of Severe Soil DroughtNARA Subscribed
Tropical montane cloud forests (TMCFs) are globally important ecosystems, acting as large carbon sinks and supporting exceptional biodiversity. However, climate‐driven declines in rainfall threaten these forests, but their responses to long‐term soil moisture deficit remain poorly understood. We implemented a 5‐year throughfall exclusion (TFE) experiment in a Peruvian TMCF, reducing soil moisture by 69.1% across a 0.09 ha plot...
Curdlan, a β-1,3/1,6-glucan found in Alcaligenes faecalis ( A. faecalis ) wall, activates innate and humoral immunity. The aim of this study is to evaluate whether pretreated rats with A. faecalis A12C could prevent sepsis disturbances and identify the immunomodulatory mechanisms involved. Experiments occurred in two stages: a survival study with 16 rats randomly divided into septic (SC) ( n = 8) and septic pretreated (SA) ( n...