Rationale Mu opioid receptor (MOR) analgesics like morphine have high intrinsic MOR efficacy but produce side effects. Lower efficacy MOR agonists like buprenorphine can produce analgesia with improved safety. We recently described a series of novel phenylmorphan-based MOR agonists with graded MOR efficacies, including several with sub-buprenorphine efficacies, and we described their acute effectiveness in mice to produce (a)...

Rationale Traumatically injured individuals can develop chronic negative psychological sequelae. Improved understanding of contributing, peri-traumatic risk factors is essential to reduce the risk of these consequences. Previous studies have found that peri-traumatic, circulating endocannabinoid concentrations are positively associated with development of post-traumatic stress disorder (PTSD), chronic pain and depression month...

Aquatic ecosystems worldwide are under severe pressure from climate change. However, studies on climate change effects on stream biota mainly focus on indicator or vulnerable species, leaving unanswered how more resilient species cope with elevated temperatures and drought, and the long-term consequences for these populations. This study therefore aims to determine the long-term population responses of a common, apparently les...

Semi‐enclosed seas present complex and nonlinear challenges to understanding climate impacts on fisheries because continental margins restrict poleward movement by taxa seeking to maintain preferred temperatures. The Gulf of Mexico (GoM), a semi‐enclosed, marginal sea surrounded by the North American continent, supports many economically and ecologically important demersal species. A comprehensive assessment of GoM demersal en...