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Global metrics quantify shifts in chronic heatNARA Subscribed
To date, research on heat extremes has primarily focused on acute events such as heatwaves. However, many regions of the globe currently face a heat hazard that can persist for months at a time. We call this hazard ‘chronic heat’ and define it here as potentially dangerous heat that lasts for 90 days or more per year. Analyzing 30 years (1993–2023) of global weather station data using three complementary metrics, this study re...
Development of a Community-engaged Research Training Workshop for Clinician-Scientists and Early-stage InvestigatorsNARA Subscribed
Community-engaged research (CEnR), a collaboration between academics and community partners, is an effective approach in addressing the social drivers of health (SDOH) and health disparities in local communities. Yet, CEnR training is often not a standard component of training programs in research or clinical programs. To meet the need for CEnR training, we developed and implemented a workshop to increase CEnR knowledge and sk...
Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apneaNARA Subscribed
Rationale Fatal opioid overdoses involving synthetic opioids have increased >10-fold over the past 8 years. Fentanyl, a potent synthetic opioid acting at the mu-opioid receptor (MOR), has largely replaced heroin as the predominant illicit opioid available. Various analogs have been synthesized from the fentanyl scaffold, including 2-furanylfentanyl, one of the most trafficked analogs from 2019 to 2024. Despite its prevalence,...
Microcosms, or miniature experimental systems, have been used to develop models and theories in ecology. However, their contribution to conservation science is unclear. We explored the application, design, and impact of microcosms in conservation science from 469 systematically identified articles published from 1986 to 2023. We used generalized linear modeling to compare cumulative citations over time for each microcosm artic...
Dynamic frailty trajectories and risk of age-related macular degeneration: a prospective cohort study in UK BiobankNARA Subscribed
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the aging population. Although frailty has been recognized as a potential risk factor, previous studies relying on static assessments cannot capture its dynamic nature. This study aims to prospectively evaluate the association between dynamic frailty trajectories and incident AMD. The baseline cohort included 462,573 UK Biobank participant...
Increased benthic biodiversity and food web recovery after decommissioning of oil and gas infrastructureNARA Subscribed
There is a global increase in the decommissioning of offshore oil and gas (O&G) infrastructure at the end of its operating lifetime. However, there is strikingly limited empirical evidence for the environmental and ecological impacts of decommissioning. Here, we employed a meta‐analytical approach on an industry benthic monitoring database to investigate the benthic biodiversity and food web properties of structures sampled in...
Heat-labile toxin (LT) from enterotoxigenic Escherichia coli (ETEC) is an important pathogenic protein. Anti-LT antibodies (Abs) induced by vaccination can neutralize the toxin and potentially prevent diarrheal secretion from ~ 60% of ETEC strains expressing LT. However, only superficial investigation of the anti-toxin response is usually conducted in clinical trials. Here, we utilized human serum samples from two clinical tri...
Thierry B.R. Chopin (1959–2024) – Innovator of Modern IMTANARA Subscribed
Siberian boreal forests have experienced increases in fire extent and intensity in recent years, which may threaten their role as carbon (C) sinks. Larch forests ( Larix spp.) cover approximately 2.6 million km 2 across Siberia, yet little is known about the magnitude and drivers of carbon combustion in these ecosystems. To address the paucity of field‐based estimates of fuel load and consumption in Siberian larch forests, we...
Can Siphon Hole Morphometrics Be Used for Population Assessments of Intertidal Soft-Shell Clams, Mya arenaria?NARA Subscribed
Measuring infaunal population dynamics relies on destructive sampling that disturbs sediments and removes animals from their habitat. Establishing effective, non-invasive sampling methods for monitoring infaunal populations can reduce the impact of scientific sampling and facilitate efficient population assessments. Using intertidal soft-shell clams ( Mya arenaria L.) in eastern Canada, we explored whether population density a...