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NARA Subscribed1
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Springer Nature1
Journal
Archives of Toxicology1
Publication Year
20261
C. Felske results 1 · Newest (Page 1/1, per page 25)
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Author: C. Felske ×Clear All Filters
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The in vitro alkaline comet assay with liver models as a complementary tool for genotoxicity assessment of N-nitrosaminesNARA Subscribed
Archives of Toxicology · 2026 · Springer
M. A. Djuari; A. Londenberg; A. Bassan; K. Cross; L. Elenschneider; S. E. Escher; J. Fahrer; J. Fangmann; C. Felske; R. Frötschl; B. Haas; G. E. Johnson; M. Vogel; R. Whomsley; C. Ziemann
N -nitrosamine (NA) impurities in pharmaceuticals represent “cohort of concern” compounds under ICH M7(R2), due to their mutagenic/carcinogenic potential, involving cytochrome P450 (CYP)-mediated metabolic activation. Increasing interest in mammalian cell-based genotoxicity/mutagenicity assays prompted our assessment of the in vitro alkaline comet assay regarding its predictive power for NAs. Here, precision-cut liver slices (...
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