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This paper introduces a comprehensive Tropical Cyclone (TC) dataset based on China’s FengYun (FY) series geostationary satellite observations in the Western North Pacific (WNP), designated as FYSATTY. This innovative dataset integrates high-resolution geostationary meteorological satellite observations with best-track data, providing a unique resource for TC monitoring and analysis in the WNP region. FYSATTY is derived from in...
Antibody–drug conjugates (ADCs) represent a rapidly evolving therapeutic modality, combining the selective targeting of monoclonal antibodies with highly potent small molecule payloads. Their inherent structural complexity demands a sophisticated and multi-faceted bioanalytical approach spanning preclinical discovery through late-stage clinical development. This white paper, developed by the ADC Working Group of the AAPS bioan...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed
Monitoring evapotranspiration to link agricultural water use with crop yield at sub-field scalesNARA Subscribed
Purpose Scientists and producers have pursued precision agriculture to increase yields and limit environmental impacts. Applying precision agriculture concepts has not been straightforward, however, because complex interactions between soil and weather govern crop growth. We hypothesize that evapotranspiration (ET) is a single metric that captures interactions between plant status, soil, topography, and weather and can be used...
Discovery of a Potent Small Molecule Antagonist of GRPR for the Treatment of PruritusNARA Subscribed
Persistent pruritus (itch) affects the quality of life, and many itch syndromes remain untreatable. Previously, we identified the gastrin-releasing peptide receptor (GRPR) playing a critical role in mediating histamine-independent itch signaling. In this study, we aimed to identify small-molecule GRPR antagonists to treat histamine-independent itch. Starting with the known small-molecule GRPR antagonist PD 176,252, we conducte...
Personalizing treatment of pancreatitis-associated chronic pain: the need for an integrated omics approachNARA Subscribed
Background Chronic pancreatitis (CP) is a progressive inflammatory disorder characterized by debilitating chronic pain and substantial healthcare burden. Pain mechanisms in CP are heterogeneous and incompletely integrated into clinical decision-making. This narrative review synthesizes data from human CP cohorts and complementary experimental models to summarize inflammatory, neuropathic, and metabolic drivers of pancreatitis-...
Distributed optical fibre sensing (DOFS) is a technology that enables continuous, real-time measurements of a range of environmental parameters along the length of a fibre optic cable. In this article, we review the recently emerged applications of DOFS techniques in physical oceanography and offer a perspective on the technology's potential for future growth within the field. The introduction of DOFS to physical oceanography...