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Mescaline Alters Cerebellar Function, Global Connectivity, and Frequency-Selective Acoustic Gating: A BOLD fMRI Study in Awake RatsNARA Subscribed
Mescaline, a 5-HT2A agonist psychedelic used ceremonially for millennia, lacks neuroimaging characterization due to its Schedule 1 status. Using pharmacological and resting-state fMRI in awake rats, we report mescaline's first comprehensive neurobiological profile. Acutely, mescaline produced cerebellar-selective BOLD suppression, suggesting functional disconnection from forebrain structures. Paradoxically, resting-state analy...
Mesoscale Brain Mapping: Bridging Scales and Modalities in Neuroimaging – A Symposium ReviewNARA Subscribed
Advances in the spatiotemporal resolution and field-of-view of neuroimaging tools are driving mesoscale studies for translational neuroscience. On October 10, 2023, the Center for Mesoscale Mapping (CMM) at the Massachusetts General Hospital (MGH) Athinoula A. Martinos Center for Biomedical Imaging and the Massachusetts Institute of Technology (MIT) Health Sciences Technology based Neuroimaging Training Program (NTP) hosted a...
Aim After environmental disasters, species with large population losses may need urgent protection to prevent extinction and support recovery. Following the 2019–2020 Australian megafires, we estimated population losses and recovery in fire‐affected fauna, to inform conservation status assessments and management. Location Temperate and subtropical Australia. Time period 2019–2030 and beyond. Major taxa Australian terrestrial a...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
SARS-CoV-2 is rapidly inactivated at high temperatureNARA Subscribed
In the absence of a vaccine, preventing the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the primary means to reduce the impact of the 2019 coronavirus disease (COVID-19). Multiple studies have reported the presence of SARS-CoV-2 genetic material on surfaces suggesting that fomite transmission of SARS-CoV-2 is feasible. High temperature inactivation of virus has been previously suggested, but n...
Conservation practitioners face difficult choices in apportioning limited resources between rare species (to ensure their existence) and common species (to ensure their abundance and ecosystem contributions). We quantified the opportunity costs of conserving rare species of migratory fishes in the context of removing dams and retrofitting road culverts across 1,883 tributaries of the North American Great Lakes. Our optimizatio...
Minimizing opportunity costs to aquatic connectivity restoration while controlling an invasive speciesNARA Subscribed
Controlling invasive species is critical for conservation but can have unintended consequences for native species and divert resources away from other efforts. This dilemma occurs on a grand scale in the North American Great Lakes, where dams and culverts block tributary access to habitat of desirable fish species and are a lynchpin of long‐standing efforts to limit ecological damage inflicted by the invasive, parasitic sea la...
Extraterrestrial hydrogeologyNARA Subscribed
Reciprocal hybrid formation of Spartina in San Francisco BayNARA Subscribed
Diversity in the tRNA LEU1 intron of the chloroplast genome of Spartina was used to study hybridization of native California cordgrass, Spartina foliosa , with S. alterniflora , introduced to San Francisco Bay ≈ 25 years ago. We sequenced 544 bases of the tRNA LEU1 intron and found three polymorphic sites, a pyrimidine transition at site 126 and transversions at sites 382 and 430. Spartina from outside of San Francisco Bay, wh...
The use of molecular markers to study patterns of genotypic diversity in some invasive alien Fallopia spp. (Polygonaceae)NARA Subscribed
Random amplified polymorphic DNA (RAPDs) and inter‐simple sequence repeats (inter‐SSRs) have been used to study clonal growth and hybridization in some non‐native, gynodioecious, invasive weeds from the genus Fallopia (Polygonaceae). At the study site (the River Kelvin, Glasgow, UK) a single genotype of Japanese knotweed ( Fallopia japonica ) was detected, consistent with all the individuals sampled being ramets of a single cl...
Molecular evidence for the maternal parentage in the hybrid origin of Spartina anglica C.E. HubbardNARA Subscribed
Spartina anglica is a textbook example of a natural amphiploid, which originated from hybridization between S. alterniflora and S. maritima . Which of these species was the maternal parent has remained a mystery. Inheritance of chloroplast DNA in most angiosperms is strictly maternal and can thus be used to test the parentage of hybrid taxa. The DNA sequence of the chloroplast leucine tRNA gene intron was used to show that the...
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