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Expansion of adult stem cells in culture increases the percent of senescent cells, reduces their differentiation capacity and limits their clinical use. Here, we investigated whether treatment with certain senotherapeutic drugs would reduce the accumulation of senescent cells during expansion of human liver stem cells (HLSCs) while maintaining their differentiation capacity. Our results demonstrate that chronic treatment with...
Archaeoseismic analysis performed in Western Sicily points to deformed archeological remains at Lilybaeum , a Punic coastal city founded in 397 B.C. at the Island’s westernmost edge. Starting from the direct observation of deformed ruins, an interdisciplinary work strategy, which included field-structural analysis, drone-shot high-resolution aerial photogrammetry, and geophysical prospecting, was employed to investigate whethe...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Which practices co‐deliver food security, climate change mitigation and adaptation, and combat land degradation and desertification?NARA Subscribed
There is a clear need for transformative change in the land management and food production sectors to address the global land challenges of climate change mitigation, climate change adaptation, combatting land degradation and desertification, and delivering food security (referred to hereafter as “land challenges”). We assess the potential for 40 practices to address these land challenges and find that: Nine options deliver me...
The European carbon balance. Part 4: integration of carbon and other trace‐gas fluxesNARA Subscribed
Overviewing the European carbon (C), greenhouse gas (GHG), and non‐GHG fluxes, gross primary productivity (GPP) is about 9.3 Pg yr −1 , and fossil fuel imports are 1.6 Pg yr −1 . GPP is about 1.25% of solar radiation, containing about 360 × 10 18 J energy – five times the energy content of annual fossil fuel use. Net primary production (NPP) is 50%, terrestrial net biome productivity, NBP, 3%, and the net GHG balance, NGB, 0.3...