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Untargeted Metabolomics Reveals Major Patterns of Metabolic Shifts in Potato Seed Tubers during StorageNARA Subscribed
To obtain comprehensive insight into metabolic changes in potato seed tubers during storage and to identify patterns associated with physiological ageing, we analysed tuber metabolite composition using untargeted metabolomics based on gas and liquid chromatography-mass spectrometry (GC–MS and LC–MS). During two seasons, seed tubers of four contrasting cultivars (Agria, Festien, Innovator, and Lady Claire) were produced in a si...
Ethics in archaeobotany: identifying current issues and initiating a declaration of principlesNARA Subscribed
This article presents the first systematic assessment of ethical concerns specific to archaeobotanical research, focusing on principles and values. Conducted by an international group of archaeobotanists, the study used an anonymous online survey to document experiences and perceptions within the archaeobotanical community with the aim of raising awareness, identifying prevalent good practices and noting points for improvement...
Temperature, but not acidification, influences the growth and lipid profile of juvenile sand whiting, Sillago ciliata (Cuvier 1829)NARA Subscribed
Seafood provides an essential source of macro‐ and micronutrients for coastal communities worldwide. Climate change is a key threat to seafood security, altering the sizes, abundances, distributions, physiology and ecological interactions of fisheries species, and increasingly, there is evidence of impacts to seafood nutritional quality. In a 12‐week mesocosm experiment, we tested the influence of projected ocean warming and a...
Enhancing protein stability while maintaining activity is a long-standing challenge in protein engineering, as modifications that benefit one property often compromise another. In this study, we leveraged a computational design strategy, CamSol Combination, to make a first step to improve the stability of purple acid phosphatase (PAP), a metalloprotein known for its distinctive pink color. PAP serves as a challenging model for...
Carbon source and weather in coastal North CarolinaNARA Subscribed
The increasing frequency of extreme weather events, including tropical cyclones, is altering the delivery and quality of organic matter (OM) exported from landscapes to estuaries. However, the mechanisms regulating these shifts, especially during multi‐year climatic oscillations, remain poorly understood. We used a new fluorescence–based mixing model to estimate dissolved OM (DOM) sources to the Neuse River Estuary, during a d...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...