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In memoriam: Carl J. CarranoNARA Subscribed
This article is a celebration of the life and work of Carl J. Carrano who, from a childhood in Long Island, New York, built a career in bioinorganic chemistry, especially in the context of metal uptake and halogen metabolism in microbes and marine organisms.
Columnanidus calitzdorpensis ichnogen. ichnosp. nov: A new Middle Pleistocene subterranean termite trace fossil from South AfricaNARA Subscribed
Termites are landscape geo‐engineers whose nesting activities substantially modify the physical and chemical properties of soils. Fossilised termite nests commonly constitute the only identifiable evidence of ancient termite activity and represent valuable trace fossil archives for reconstructing past environments. Here, we describe a new ichnogenus and ichnospecies, Columnanidus calitzdorpensis ichnogen. ichnosp. nov., from Q...
Effects of repeated treatment with opioids that vary in mu opioid receptor efficacy on pain-depressed locomotor behavior in miceNARA Subscribed
Rationale Mu opioid receptor (MOR) analgesics like morphine have high intrinsic MOR efficacy but produce side effects. Lower efficacy MOR agonists like buprenorphine can produce analgesia with improved safety. We recently described a series of novel phenylmorphan-based MOR agonists with graded MOR efficacies, including several with sub-buprenorphine efficacies, and we described their acute effectiveness in mice to produce (a)...
Global annual cropland dynamics 2015–2024NARA Subscribed
Bottom‐tow gear fisheries (trawls and dredges) produce ~24 million mt of harvest annually, representing a globally important animal‐sourced food system. While many are currently sustainably managed, growing concern over the potential for ecosystem impacts from bottom‐tow gears has increased pressure to improve these fisheries. We assembled an international working group of > 30 contributors, including fishing industry particip...
Global patterns and regional insights into kelp forest protection, restoration, and stewardshipNARA Subscribed
Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed
Effectiveness of passive trapping and sweep netting for insect pollinator sampling in turf communitiesNARA Subscribed
Pollinator communities in urban and peri-urban turfgrass remain poorly characterized despite the ubiquity of lawns and growing interest in management practices that enhance floral resources within these otherwise resource-limited environments. To address this gap, we evaluated the effectiveness of active (sweep netting at multiple times of day) and passive (molasses traps and blue, white, and yellow pan traps) sampling methods...
Purpose The DANFLU-1 trial suggested lower incidence of hospitalizations for pneumonia and influenza, respiratory disease and all-cause mortality among older adults receiving high-dose (HD-IV) versus standard-dose (SD-IV) influenza vaccine. This study assessed the relative effectiveness of HD-IV versus SD-IV according to comorbidity in elderly individuals. Methods This was a post-hoc analysis of the DANFLU-1 randomized control...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Annual killifishes of the genus Nothobranchius live in seasonal water bodies in Eastern Africa. Adults die at the end of the rainy season when seasonal pools desiccate but diapaused embryos persist in the sediments and hatch in subsequent rainy seasons. Embryos use environmental cues to determine optimal hatching conditions to begin a new generation. We simulated a predation event by crushing Nothobranchius embryos and tested...