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The phenotypic diversity between castes in social species has been associated with increased regulation of gene expression. while the regulatory role of transcription factors (TFs) in the social transitions of Hymenoptera (bees, ants and wasps) is well studied, it remains poorly explored in Blattodea (cockroaches and termites). By analysing three cockroach and five termite genomes, we show that while Blattodea share some conve...
Tobacco use remains the leading preventable cause of cancer mortality worldwide, with marked disparities in cancer incidence and outcomes across racial and ethnic groups. This study investigates the genetic determinants of tobacco carcinogen metabolism among smokers, focusing on ancestry-informative markers (AIMs) near genes involved in metabolic activation (Phase I), detoxification (Phase II), and transport (Phase III) of tob...
Correlation between DNA methylation and transcriptomic changes in golden Asian sea bass ( Lates calcarifer ): An integrated approachNARA Subscribed
Lates calcarifer , commonly known as barramundi perch, Asian sea bass or barramundi, is a significant aquaculture species across the Indo‐Pacific. Barramundi typically exhibit a silver to bronze wild‐type (WT) skin colour, with occasional golden (xanthic) variants of commercial interest. Although previous studies have identified gene expression differences between golden and WT variants, the genetic mechanism driving golden co...
Acoustic telemetry reveals high site fidelity of yellow‐phase American eels Anguilla rostrata in a large riverNARA Subscribed
Movement patterns and habitat use of yellow‐phase American eels Anguilla rostrata in the Wolastoq/Saint John River were examined using acoustic telemetry. Tracking 72 tagged yellow‐phase eels from late summer 2021 to autumn 2023 revealed overall restricted longitudinal movements (mean linear range ± standard deviation [SD] 6.4 ± 10.9 km) and high site fidelity. However, two eels exhibited small‐scale (20–25 km) seasonal moveme...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Marine species with high fecundity and larvae with long-distance dispersal potential can have complex population genetic patterns. Characterizing population structure in these species is important for understanding their ecology and life history and designing management strategies. The eastern oyster (Crassostrea virginica) is both ecologically and economically important but has experienced recent population declines. Characte...
The Marsupial Database: A comprehensive dataset on the ecology and life history of American and Australasian marsupialsNARA Subscribed
Marsupials are an important but typically neglected group of mammals that have been overlooked in many comparative analyses of vertebrate ecology and life history evolution. In order to address this knowledge bias, we have developed The Marsupial Database. The Marsupial Database contains traits for a phylogenetically diverse set of 414 extant and recently extinct (last 200 years) species from all seven modern marsupial orders...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Spatial memory in Alzheimer’s disease 5XFAD mice is enhanced by XPO1 inhibitor KPT-330NARA Subscribed
The proteostatic decline in Alzheimer’s disease is well established, and improvement in proteostasis could potentially delay cognitive impairment. One emerging entry point to modulate proteostasis is the regulation of nucleo-cytoplasmic partitioning of proteins across the nuclear pore via karyopherins. The nuclear exportin XPO1 is a key regulator of proteostasis by driving the assembly of ribosomes and by modulating the proces...
Beyond strength: dietary nitrate augments self-selected functional mobility after resistance training in middle-aged adultsNARA Subscribed
This study aimed to assess whether dietary nitrate supplementation with resistance training (RT) augments gait performance and functional mobility in inactive middle-aged and older adults. We hypothesized that combining nitrate-rich beetroot juice (BRJ) with RT would yield improvements in gait and functional mobility compared to RT with nitrate-depleted beetroot juice placebo (PLA) supplementation. In this 12-week, randomized,...
Proximity to natural habitat is known to enhance pollination services in large‐scale agriculture, but it remains unclear whether this holds in tropical smallholder farms. These systems are embedded in ecologically complex landscapes, central to global food security, and depend heavily on biodiversity‐derived ecosystem services. We conducted a systematic review and meta‐analysis of 35 studies assessing the relationship between...
Verbal fluency dual-tasks show greater age-related cognitive-motor interference: a meta-analysis of walking performanceNARA Subscribed
A substantial body of literature has examined gait during cognitive dual-tasking in younger and older adults. However, it remains unclear how, and to what extent, different cognitive tasks uniquely influence gait. This meta-analysis quantified age-related differences in gait speed during dual-task walking. Importantly, we examined cognitive task as a potential moderator. We searched Web of Science for studies comparing young a...