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Genetic studies have differentiated three subspecies of humpback whales: Megaptera novaeangliae novaeangliae in the North Atlantic, M. n. australis in the Southern Hemisphere and M. n. kuzira in the North Pacific. However, these analyses did not include samples from the Arabian Sea humpback whale population (ASHW). Historic, behavioural, and previously published genetic data suggested that ASHWs are a discrete, isolated and re...
Pain responses following resistance exercise with and without blood flow restriction in individuals with multiple sclerosisNARA Subscribed
Purpose Pain is a common symptom among individuals living with multiple sclerosis (MS). Exercise-induced hypoalgesia (EIH), a reduction in pain sensitivity following resistance exercise, typically requires high loads. Blood flow restriction (BFR) training may offer a lower-load alternative to elicit EIH. This investigation aimed to assess EIH responses following resistance exercise with and without BFR in individuals with MS....
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Environmental factors shape the distributions of organisms and their underlying patterns of genetic variation. When climate changes rapidly, organisms that are adapted to current environments may become maladapted to future climates. Long‐lived tree species are especially susceptible to climate maladaptation due to their sessile nature and long generation times. Understanding how foundational tree species will respond to futur...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Lakes and reservoirs play a key role in the global carbon cycle, representing important carbon sinks and sources within the terrestrial landscape under different environmental conditions. Changes in climate and land use have led to increased air and surface water temperatures; increased occurrence and duration of hypolimnetic anoxia; and altered hydrology and nutrient loading, which have the potential to affect how these fresh...
Sitting time and risk of cancer incidence and cancer mortality in postmenopausal women: the Women’s Health Accelerometry CollaborationNARA Subscribed
Purpose Few studies have explored whether accelerometer-measured sedentary behavior increases cancer risk. We examined the associations of accelerometer-measured daily sitting time and mean sitting bout duration classified by the Convolutional Neural Network Hip Accelerometer Posture (CHAP) machine-learned algorithm with incidence of any cancer, incidence of 13 physical activity-related cancers, and cancer mortality among post...
Climate change is a major threat to biodiversity, and migratory animals are particularly vulnerable, due partly to their reliance upon good resource availability across a network of sites at specific times. Migrants perform vital ecosystem functions, transferring significant resources across large spatial scales, but the impacts of climate change on the ability of individuals to complete these journeys are poorly studied. Coll...