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Oxygen is critical for nearly all life on Earth, including aquatic species that breathe dissolved oxygen in both freshwater and marine systems. The rapid, global, and anthropogenic loss of dissolved oxygen known as “aquatic deoxygenation” threatens life in these environments, the human communities that depend on them, and Earth system stability long‐term. Recognizing the important and increasingly widespread effects of aquatic...
Ecosystem engineering by primary consumers increases long-term benthic primary production in Lake Mývatn, IcelandNARA Subscribed
Ecosystem engineers impact ecosystems by changing the physical environment in which species interact. In Lake Mývatn, Iceland, larvae of the midge Tanytarsus gracilentus function as ecosystem engineers by building tubes in the sediment that solidify the benthic surface and create a 3-dimensional structure on which microalgae can grow. To assess the ecosystem-scale effect of midge engineering, we took advantage of the natural h...
Coral bleaching impacts cortisol levels of coral reef fishesNARA Subscribed
Mass coral bleaching events, driven by increasingly frequent and intense marine heatwaves, pose a growing threat to coral reefs. While declines in reef fish populations are often associated with bleaching-induced coral mortality, physiological mechanisms underpinning these declines remain poorly understood. We investigated hormonal and energetic responses in three Pomacentrus species with varying dependency on live corals on t...
Marmot gut microbiomes are stable against dietary variationNARA Subscribed
Regional Variation in Phragmites australis Reproductive Traits and Seedling Performance in North AmericaNARA Subscribed
Seedling recruitment is an important mode of establishment utilized by many invasive plants. In widespread invasive plants, regional variation in the rates of seedling recruitment can contribute to differences in invasion intensity across regions. In this study, we examined regional variation in reproductive traits and seedling performance in a cosmopolitan invasive wetland grass, Phragmites australis . We tested whether nitro...
While climate warming is widely predicted to reduce body size of ectotherms, evidence for this trend is mixed. Body size depends not only on temperature but also on other factors, such as food quality and intraspecific competition. Because temperature trends or other long‐term environmental factors may affect population size and food sources, attributing trends in average body size to temperature requires the separation of pot...
Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitorsNARA Subscribed
We have recently shown that multiple tRNA synthetase inhibitors can greatly increase lifespan in multiple models by acting through the conserved transcription factor ATF4. Here, we show that these compounds, and several others of the same class, can greatly upregulate mammalian ATF4 in cells in vitro, in a dose dependent manner. Further, RNASeq analysis of these cells pointed toward changes in protein turnover. In subsequent e...
Effects of elevated water temperature on cutthroat trout angler catch rates and catch‐and‐release mortality in Idaho streamsNARA Subscribed
The concern is growing that angling may need to cease at elevated summer water temperatures to protect salmonid populations. Cutthroat Trout Oncorhynchus clarkii in streams were caught, marked and released using artificial dry flies at temperatures from 13.5 to 25.7°C to evaluate whether subsequent recapture with backpack electrofishing (an index of relative survival) was reduced when the water temperature was elevated at the...
Kissing bugs (Hempitera: Reduviidae) are obligately and exclusively blood feeding insects. Vertebrate blood is thought to provide insufficient B vitamins to insects, which rely on symbiotic relationships with bacteria that provision these nutrients. Kissing bugs harbour environmentally acquired bacteria in their gut lumen, without which they are unable to develop to adulthood. Rhodococcus rhodnii was initially identified as th...
Reconstructing midge consumer–resource dynamics using carbon stable isotope signatures of archived specimensNARA Subscribed
Population cycles can be caused by consumer–resource interactions. Confirming the role of consumer–resource interactions, however, can be challenging due to an absence of data for the resource candidate. For example, interactions between midge larvae and benthic algae likely govern the high‐amplitude population fluctuations of Tanytarsus gracilentus in Lake Mývatn, Iceland, but there are no records of benthic resources concurr...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...