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Accounting for human–nature linkages in area‐based conservation monitoring through social–ecological indicator bundlesNARA Subscribed
As the coverage of area‐based conservation increases across the globe, it is critical to improve understanding of the social and ecological outcomes of such measures and the pathways to their outcomes. A social–ecological systems approach to monitoring and evaluation is increasingly advocated; yet, applications remain scarce. We sought to facilitate operationalization of this approach through prioritization of indicators when...
A large number of drugs and compounds produced by the chemical and agrochemical industry, often referred to as ‘non-genotoxic carcinogens’ (NGC), score as tumour promotors in rodent models. It is unclear whether these compounds act similarly in humans. The most extensively investigated compounds have been the anti-convulsive drugs, phenobarbital (PB), and phenytoin. Liver tumours induced by PB are dependent upon the activation...
The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservationNARA Subscribed
The International Mouse Phenotyping Consortium (IMPC) is building a catalogue of mammalian gene function by producing and phenotyping a knockout mouse line for every protein-coding gene. To date, the IMPC has generated and characterised 5186 mutant lines. One-third of the lines have been found to be non-viable and over 300 new mouse models of human disease have been identified thus far. While current bioinformatics efforts are...
Evidence is reported for balancing selection acting on variation at major histocompatibility complex (MHC) in wild populations of brown trout Salmo trutta . First, variation at an MHC class I ( satr‐uba )–linked microsatellite locus ( mhc1 ) is retained in small S . trutta populations isolated above waterfalls although variation is lost at neutral microsatellite markers. Second, populations across several catchments are less d...
18th International Mouse Genome ConferenceNARA Subscribed
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