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Five years of national airborne pollen monitoring in South Africa: biome-specific calendars to inform allergy diagnosis and preventionNARA Subscribed
Pollen monitoring is crucial for understanding seasonal patterns, supporting allergy diagnosis and informing early warning tools to mitigate allergic diseases. The Southern Hemisphere lacks long-term pollen seasonal data, with extremely few records from Africa. We present pollen calendars based on five years of data from South Africa. Airborne pollen from 2019 to 2024 across South African biomes was collected in seven cities u...
Direct ultrastructural validation of endocrine cell identity in zebrafish pancreatic isletsNARA Subscribed
The zebrafish is widely used to study glucose homeostasis, diabetes, and endocrine cell plasticity, yet a definitive ultrastructural characterization of adult pancreatic endocrine cell types has remained incomplete. Here, we combined transmission electron microscopy with hormone-specific immunogold labeling to define the ultrastructural characteristics of the major endocrine cell populations in adult zebrafish pancreatic islet...
Temperate Forest Floors: Ecosystem Hubs in Transition?NARA Subscribed
The forest floor (FF) plays a key role in carbon, nutrient, and water cycling. It is the biologically most active compartment of forest soils, highly responsive to environmental conditions. Yet, its response to current changes in environmental conditions and forest management is understudied. Temperate forests are among the best studied ecosystems globally, providing the necessary ecological and biogeochemical background infor...
Terrigenous inputs link nutrient dynamics to microbial communities in a tropical lagoonNARA Subscribed
Nutrient availability drives community structure and ecosystem processes, especially in tropical lagoons that are typically oligotrophic but often receive allochthonous inputs from land. Terrestrially derived nutrients are introduced to tropical lagoons by surface runoff and submarine groundwater discharge, which are influenced by seasonal precipitation. However, terrigenous inputs presumably diminish along the onshore–offshor...
Contractile effects of stimulation of D1-dopamine receptors in the isolated human atriumNARA Subscribed
Dopamine receptors have been claimed not to directly increase contractility in the human heart. Therefore, we performed contraction experiments in isolated electrically driven human atrial preparations (HAP). For comparison, we performed contraction experiments with left atrial preparations of transgenic mice which harbor a cardiac overexpression of human D 1 -dopamine receptors (D 1 -TG). In D 1 -TG, first we noted that dopam...
Studies on the mechanisms of action of MR33317NARA Subscribed
MR33317 was synthesized as an acetylcholinesterase-inhibitor and an agonist at brain 5-HT 4 -receptors. MR33317 might be used to treat Morbus Alzheimer. This therapeutic action of MR33317 might be based on MR33317´s dual synergistic activity. We tested the hypothesis that MR33317 also stimulates 5-HT 4 -receptors in the heart. MR33317 (starting at 10 nM) increased force of contraction and beating rate in isolated atrial prepar...
The SW highlands of Ethiopia are a key component in the evolution of modern humans. Yet, palaeoecological studies, essential to understand past human-vegetation relationships, are almost inexistent in this region. In this paper, we present an anthracological study of the Sodicho rock shelter, located at 1,930 m a.s.l. in the SW Ethiopian Afromontane forest zone, reconstructing the past woody vegetation since the end of the Afr...
Persistent net release of carbon dioxide and methane from an Alaskan lowland boreal peatland complexNARA Subscribed
Permafrost degradation in peatlands is altering vegetation and soil properties and impacting net carbon storage. We studied four adjacent sites in Alaska with varied permafrost regimes, including a black spruce forest on a peat plateau with permafrost, two collapse scar bogs of different ages formed following thermokarst, and a rich fen without permafrost. Measurements included year‐round eddy covariance estimates of net carbo...
While forest productivity and biodiversity are expected to be correlated, prioritizing either forest productivity or biodiversity can result in different management. Spatial quantification of the congruence between areas suitable for either one can inform planning. Here we quantify the relationship between net primary productivity of European forests and biodiversity of mammals, birds, reptiles, amphibians, and butterflies bot...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
The extensive clinical and genetic heterogeneity of congenital limb malformation calls for comprehensive genome-wide analysis of genetic variation. Genome sequencing (GS) has the potential to identify all genetic variants. Here we aim to determine the diagnostic potential of GS as a comprehensive one-test-for-all strategy in a cohort of undiagnosed patients with congenital limb malformations. We collected 69 cases (64 trios, 1...