C. Partridge results 38
· Newest (Page 1/2, per page 25)
Author: C. Partridge ×Clear All Filters
Search Results
The administration of therapeutic proteins, such as monoclonal antibodies (mAbs) may result in the formation of anti-drug antibodies (ADA), but there is limited publicly available data for biotherapeutics with exogenous targets or with targets in low abundance systemically. ADAs can impact a biotherapeutic’s safety, efficacy, and pharmacokinetics, so evaluation of immunogenicity is required for all therapeutic proteins. This a...
Lessons learned through participatory bird-window collision research on a university campusNARA Subscribed
Bird populations face many threats worldwide, including collisions with anthropogenic structures such as buildings’ windows. Bird-window collisions are gaining attention, but research and mitigation often face barriers including collision surveying guidelines, funding availability, and retrofitting costs and approvals. Beginning in 2022, we conducted research about bird-window collisions on an urban university campus to engage...
Global phylogeography of hyperdiverse lanternfishes indicates sympatric speciation in the deep seaNARA Subscribed
Aim Lanternfishes (Myctophidae) are one of the most species‐rich families of mid‐water fishes. They inhabit the mesopelagic zone, where physical barriers to dispersal and gene flow are permeable. Thus, modes of speciation that rely exclusively on geographical separation are potentially of less importance than those that rely more prominently on evolution of assortative mating through divergent habitat use and/or sexual signals...
A cell-based assay was developed to detect neutralizing anti-drug antibodies (NAbs) against odronextamab, a CD20xCD3 bispecific monoclonal antibody (mAb) under investigation for treatment of CD20+ B cell malignancies. In this assay, odronextamab bridges between two cell types, CD20-expressing HEK293 cells and CD3-expressing Jurkat T cells that generate a luciferase signal upon CD3 clustering. Patient samples containing NAbs di...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Monoclonal antibodies (mAbs) are a leading class of biotherapeutics. In oncology, patients often fail on early lines of biologic therapy to a specific target. Some patients may then enroll in a new clinical trial with a mAb specific for the same target. Therefore, immunoassays designed to quantify the current mAb therapy or assess immunogenicity to the drug may be susceptible to cross-reactivity or interference with residual p...
In 2011, the enigma of “mystery circles,” small but complex underwater structures first observed by divers from southern Japan in 1995, was solved when a new species of pufferfish, white‐spotted pufferfish ( Torquigener albomaculosus Matsuura 2014), was identified as the responsible agent. To date these circles have been described only from Japan, where they are formed on a sandy seafloor in water depths less than 30 m. A surv...
Phototactic tails: Evolution and molecular basis of a novel sensory trait in sea snakesNARA Subscribed
Dermal phototaxis has been reported in a few aquatic vertebrate lineages spanning fish, amphibians and reptiles. These taxa respond to light on the skin of their elongate hind‐bodies and tails by withdrawing under cover to avoid detection by predators. Here, we investigated tail phototaxis in sea snakes (Hydrophiinae), the only reptiles reported to exhibit this sensory behaviour. We conducted behavioural tests in 17 wild‐caugh...
Evidence of paternal nutrient provisioning to embryos in broad‐nosed pipefish Syngnathus typhleNARA Subscribed
In two experiments, radioactively labelled nutrients (either 3 H‐labelled amino‐acid mixture or 14 C‐labelled glucose) were tube‐fed to brooding male Syngnathus typhle . Both nutrients were taken up by the males and radioactivity generally increased in the brood pouch tissue with time. Furthermore, a low but significant increase of 3 H‐labelled amino acids in embryos was found over the experimental interval (48 h), whereas in...