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The functional and molecular definition of progenitors giving rise to blood vessel endothelium in vivo remains disputed. Upon investigating the overlap of seemingly divergent reports currently defining putative endothelial progenitor cells (EPCs) using single-cell RNA-sequencing and flow cytometry, Protein C Receptor (PROCR) and Platelet-Derived Growth Factor Receptor Alpha (PDGFRA) largely overlapped with previously character...
Gene-environment interactions, leading to immune-brain cross-talk and neuroinflammation are increasingly recognised in neurodevelopmental disorders (NDDs), such as autistic regression and paediatric acute onset neuropsychiatric syndrome (PANS). Nonsteroidal anti-inflammatory drugs, including ibuprofen, provides relief to some neuropsychiatric symptoms, however, the therapeutic mechanisms are unclear. We describe the benefit of...
Performance-based design of an aluminium-core buckling-restrained knee-braced truss moment frameNARA Subscribed
The buckling-restrained knee braced-truss moment frame (BRKB-TMF) is a novel seismic force-resisting system that offers several advantages over conventional truss moment frames. It can be designed per performance-based plastic design (PBPD) methodology to confine inelastic activities to the buckling-restrained braces (BRBs) and column bases, whereas keeping all other structural elements in the elastic range. An innovative BRB...
Evaluation of coal combustion residuals in cement systemsNARA Subscribed
Length‐Based Spawning Potential Ratio Assessment of Key Species From a Remote Recreational Fishery at Diego Garcia, Indian OceanNARA Subscribed
Recreational fisheries in remote regions often operate under limited regulation and data availability, presenting challenges for sustainable management. Diego Garcia, located within the Chagos Marine Protected Area, hosts a unique recreational reef fishery embedded within a highly protected environment. We assessed the stock status of five key species— Lutjanus bohar , L. gibbus , L. monostigma , Caranx melampygus , and Variol...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...